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Research Associate II - Protein Biochemistry

City of Hope
Duarte, California
Closing date
Jan 11, 2023

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Life Sciences, Biochemistry
Position Type
Full Time
Organization Type

Job Details

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes, and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope's commitment to Diversity, Equity, and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds, and experiences to our work -- and that our teams align with the people we serve to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds, and perspectives; this is reflected in our work and represented in our people.

Position Summary

Under the supervision of Dr. Anna Wu, the Research Associate II will perform a variety of research experiments that involve protein expression and characterization, tumor cell lines/ tissue culture, mouse tumor models conduct imaging studies. The RAII should be interested in reading scientific articles, contributing original ideas to the laboratory research; compiling reports of laboratory experiments and results; standardizing new techniques and training other staff on these techniques.

Protein biochemistry skills that are used in the lab include protein expression, purification (chromatography), characterization (ELISAs, flow cytometry, SDS-PAGE), conjugation, and radiolabeling. Mammalian cell culture is employed for protein production, functional assays, and tumor induction. Preclinical studies will involve tumor implantation and monitoring, in vivo imaging, tissue harvest and immunological profiling, and therapy studies including targeted radionuclide therapy.

Research in the Wu lab spans basic and translational science in a collaborative, interdisciplinary, and dynamic environment that values initiative, communication, professionalism, and teamwork. Dr. Wu is eager to mentor scientists of all backgrounds who want to go on to develop a productive career in academic medicine or science and will provide opportunities to help the RA II achieve their career goals.

Responsibilities include:
  • Utilize established protocols to perform a variety of research experiments, both in vitro (in cancer cell lines) and in vivo (in murine models). Record and validate results for accuracy and completeness.
  • Maintain thorough and accurate records of methodology and results. Analyze, compile, and graph data to present at lab meetings.
  • Ensure that all laboratory activities are carried out in compliance with safety procedures and guidelines.

Basic education, experience and skills required for consideration:
  • Bachelor's degree in life sciences or other related field with 2 years of experience or Master's degree in life sciences or other related field with 1 year of experience is required.
  • Experience with protein biochemistry, radiolabeling, cell culture and murine models is preferred.
  • A desire to work in a collaborative, interdisciplinary lab environment that values communication, initiative, professionalism, and teamwork.

Additional Information:

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.
  • Dr. Wu's research is currently supported by an NIH R01 grant from the National Cancer Institute and internal funds from City of Hope.
  • Research findings from Dr. Wu and colleagues have been published in Cancer Research, Clinical Cancer Research, Molecular Cancer Therapy, Journal of Nuclear Medicine, Proceedings of the National Academy of Science, and numerous other journals.
  • To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.

The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate's experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

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