Expert Scientist - Downstream, Protein and mRNA Vaccines

Employer
GSK
Location
Rockville, Maryland
Salary
Competitive
Closing date
Oct 2, 2022

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Expert Scientist, Downstream Process Development, Mammalian Expression Technology Center of Excellence

Are you energized by a challenging role in biology, where scientific demand is driving team growth? If so, this Expert Scientist role would be a great opportunity to consider.

The Mammalian expression technology Center of Excellence (Technical Research & Development, GSK Vaccines) is seeking an enthusiastic, experienced, and motivated Expert Scientist with a strong understanding and experience in separation technology to drive downstream process development for CHO protein subunit and mRNA - based vaccines. Located in Rockville, MD, the position will contribute to the success of the GSK CHO protein subunit and mRNA based platform.

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following…

CHO protein subunit-based vaccine platform specific responsibility:
  • Kick-start design and development of backbone downstream processes CHO protein subunit vaccine antigen for company pipeline projects in early stage up to Phase I.
  • Facilitate process transfer to development units for late-stage development/life cycle management in Global Cell& Viral Drug Substance organization.
  • Streamline/harmonizing vaccine antigen development workflows related to downstream process development and tech transfer.
  • Lead the downstream process fit evaluation for CHO cell line development and clone selection.
  • Lead the tool antigen production to support antigen design and proof-of-concept study in preclinical/early discovery function.


mRNA based vaccine platform specific responsibility:
  • Drive development & optimization of a clinical & commercial manufacturing processes for the purification of mRNA and DNA plasmid template
  • Partner with mRNA downstream process development scientists from nucleic acids vaccines center of excellence to drive company pipeline project execution and mRNA separation technology innovation


Generic responsibility:
  • Independently design and execute laboratory experiments.
  • Partner with diverse team members from various functions, multiple countries, and members at various levels in organization
  • Benchmark specific technologies in own functional area to bring technology to state of the art
  • Solve complex problems through analytical thinking to identify and understand alternatives using knowledge gained through formal education, experience, and sound judgment
  • Prepare oral and written reports to communicate scientific findings and to support project documentation and CMC submissions
  • Comply with data integrity requirements for laboratory work


Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • Advanced Degree (Master with 6 years or PhD with 2 years of relevant experiences) in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology, Bioengineering, or a related scientific field
  • 2 years experience in protein and mRNA purification or experience of purification of biomolecule
  • 2 years experience with different purification techniques such as chromatography, tangential flow filtration (TFF) and associated instrumentation such as Akta chromatography systems and Unicorn software
  • 2 years experience with bioanalytical assays associated with purification processes, such as SDS-PAGE, Western blotting, HPLC, etc.
  • 2 years experience in research and development in a Biopharmaceutical industry or government laboratory setting.
  • 2 years experience in experimental design and be able to independently execute laboratory experiments


Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Communicate effectively with regular verbal and formal updates to project teams and management.
  • Understanding of purification of biologics, specifically complex protein subunit and large size mRNA, including process scale-up
  • Experience with different purification techniques such as Tecan high-throughput miniature chromatography system
  • Understanding of Quality by Design and the development of a process control strategy
  • Design and execute DOE studies & high-throughput screen for purification process improvements and advancements including parameter optimization, scale-up, process window determination and process capability evaluation
  • Strong hands-on experience with a wide range of purification techniques for large molecules( e.g. protein subunit and large size mRNA) including affinity capture, ion exchange and hydrophobic interactions.
  • Knowledge of technology transfer and GMP manufacturing
  • Be able to rapidly acquire project understanding and apply professional knowledge to project improvement.
  • Demonstrated ability to efficiently work in a fast paced and fluid environment, changes in priority and timeline restrictions


Why GSK:

We're combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.
In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention.
*LI-GSK

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.

GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.

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Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

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