Pfizer's Centers for Therapeutic Innovation (CTI) is an outward facing research unit that partners with leading academic researchers to translate novel discoveries into therapies that change patients' lives. CTI laboratories in Manhattan and San Francisco have assembled a cross-disciplinary team of Postdoctoral Fellows to explore the underlying tenets of disease biology in the integrated space of DNA damage response pathways, chromatin biology, cancer drug tolerance, heterogeneity and immunology/inflammation. This is a unique opportunity for a driven, exceptional PhD-level scientists to leverage their expertise and develop their scientific acumen & drug discovery skills while collaborating with multidisciplinary research teams at Pfizer and academic subject-matter experts.
Successful candidates will work collaboratively with biology teams, project teams and other post-docs within the Pfizer post doc community to further our understanding of chromatin biology, DNA damage response, cancer drug tolerance, heterogeneity, innate immunity and other areas of emerging science. While performing independent, cutting-edge research, Postdoctoral Fellows will join forces with experienced drug hunters, colleagues focusing on target identification and validation, hit discovery, as well as pre-clinical animal studies and safety, with the goal of making clinically-relevant, groundbreaking discoveries and publishing their work in high-impact journals. ROLE RESPONSIBILITIES
- Demonstrate deep scientific and technical expertise harnessed to advance our understanding in the fields of heterogeneous drug responses, chromatin biology and/ or innate immunity, produce high-impact publications, present at conferences and ultimately contribute to the delivery of novel, life-changing therapies for patients.
- Independently design and test biological hypotheses in the lab or bioinformatically, while also leveraging the breadth of expertise available from other Postdoctoral Fellows and subject matter experts across Pfizer and the external academic collaborative network.
- Execute targeted in vitro and in vivo experiments, while leveraging state of the art technologies and resources to address fundamental questions regarding cancer drug resistance mechanisms that can uncover novel therapeutic angles in this space.
- Generate, organize, analyze, interpret data, and identify areas where key knowledge is lacking. Proactively seek new scientific leads via genetics & AI-based resources, literature, conferences and key opinion leaders with the goal of refining scientific hypothesis and expediting experimental plans.
- Effectively communicate results at internal and external events and proactively contribute to the continued scientific growth at Pfizer.
- Contribute to a culture that embraces scientific excellence, effectiveness, and team-work.
- Recent Ph.D. in molecular and cell biology, cancer biology, epigenetics and chromatin biology, immuno-oncology, or related fields, with a strong track record of scientific publications.
- Expertise in a number of different areas welcomed, examples: molecular and cell biological techniques, including genome editing methods, protein and chromatin biochemistry, assays that assess chromatin states, multi-color flow cytometry, bioinformatics analysis and/ or in vivo models for oncology and other therapeutic areas.
- Must have good communication, organizational and planning skills, and the motivation and ability to work in a start-up environment within a larger organization, independently and as part of a team.
- Excellent verbal and written communication skills. Ability to quickly master new concepts and techniques.
- Direct experience with cancer cell heterogeneity, transposable element biology, nucleic acid sensing mechanisms, innate immunity, chromatin biology, senescence and/ or DNA damage
- Eligible for Employee Referral Program
- Eligible for Relocation Assistance
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Research and Development