This is an exciting opportunity for a brilliant PhD level scientist to join a world leading Vaccines Research & Development environment. You'll be channeling your passion for science and helping to revolutionize the future of Vaccines R&D at GSK whilst fostering strong foundations for a career in cutting edge science.
Do you want to be part of a company investing in scientific and technical excellence to develop a pipeline of new products to meet the needs of patients across world? Please read on for more details on this unique opportunity and details on how to apply. Project Title: Next Generation High-Throughput Screening of Vaccine Candidates Project proposal:
Vaccine research is currently undergoing a technological revolution that is enabling the accelerated development of new vaccines and rapid response to public health needs. The successful candidate will become a leader in GSK's effort to develop new strategies for the high-throughput screening of vaccine candidates within Preclinical Research and Development. This work will expand our fundamental understanding of vaccine platforms, contribute to the design of next generation RNA vaccines, and enable the rapid selection of optimal vaccine candidates on short timelines. Responsibilities:
Within the US Protein Biochemistry research team, you will design, manage, and implement high-throughput screening assays to measure the performance of novel protein antigen designs and their incorporation into RNA vaccine candidates. You will consider both the properties of the RNA vector and protein antigen expressed in highly paralleled and miniaturized assays. You will also collaborate directly with both internal and external stakeholders to advance our capabilities for the organization and analysis of large datasets, implementation of new technologies for the automation of lab experimentation, and analysis of the resulting data to increase our fundamental understanding of protein antigens and RNA vaccines. You will be expected to contribute to the project by proposing research strategies, updating relevant knowledge, communicating project results (internally and externally), and writing scientific communications. To be successful in this role you should have:
Preferred qualifications/opportunities for training:
- PhD in Biochemistry, RNA biology, or Cell biology
- Expertise in cell culture and cell-based assays
- Expertise in the measurement of protein properties including protein expression, thermostability, and/or antigenicity
- Understanding of protein antigens and antibodies
- Basic molecular biology techniques for the modification of DNA plasmids
- Be highly organized, able to handle large datasets, and deal with complexity
- Strong problem-solving, prioritization, and self-directional abilities
- Excellent written and oral communication skills in English. Ability to convey scientific messages across multidisciplinary functions
- Excellent interpersonal skills. Demonstrated ability to work in collaborative teams.
What is Vaccines Scientific Leaders Program?
- Hands-on experience in the implementation of lab automation (Andrew+, Tecan, Hamilton)
- Advanced molecular biology skills, generation of plasmid and/or phage display libraries
- Hands-on experience producing/handling RNA
- Experience with microplate readers and designing parallel experimental strategies
- Experience with high-throughput assay development, fluorescence measurements, high-content imaging and/or cell-based assays
- In depth knowledge protein antigen optimization and vaccine development
- Understanding of the design and properties of RNA vaccines
- Experience with Data Science and the analysis of large multi-parameter datasets
The Scientific Leaders Program in Vaccines is a 2-year global program which builds a pipeline of early career scientists with the right expertise, technical capabilities and behaviors to drive the future in Vaccines Research and Development. How does the Vaccines Scientific Leaders Program work?
You will spend two years working on a key development project, contributing to key strategic areas of our Vaccines R&D business. We have three location options; Italy, Belgium or US which aligns to our Vaccine R&D hubs. Working on challenging projects will provide you with in-depth knowledge of the ways in which Science and Technology is being applied across R&D in GSK. All associates will be contributing to our mission to improve the quality of human life, by enabling people to do more, feel better and live longer - all while fostering strong foundations for a future career in science. Is the Vaccines Scientific Leaders Program for you?
This is a scientific/technical leadership position where you will be empowered to be innovative, collaborative, decisive and bold to solve novel R&D problems. On completion of the 2-year program we aim to bring you on-board into available technical leadership roles that best suits business' needs and your abilities.We need Scientific leaders to help embed modern Scientific principles and ways of working within the vaccines R&D organisation. Available Location: US - Rockville , Maryland
We recommend you apply as soon as possible, because we accept ongoing applications and will close this vacancy once we have enough applications.
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At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.
GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.
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