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Investigator, Drug Substance Development

Employer
GSK
Location
Collegeville, Pennsylvania
Salary
Competitive
Closing date
Sep 23, 2022

View more

Discipline
Other, Other
Job Type
Group Leader/Principal Investigator
Organization Type
Pharma
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GSK is seeking a proactive chemist to join Drug Substance Development at our US R&D Hub located in Upper Providence, PA. Our Drug Substance Development group supports the small molecule portfolio in GSK Pharma R&D with an inter-disciplinary team of process chemists, chemical engineers, and materials science experts by developing the synthetic routes and associated manufacturing processes that turn those molecules into medicines. Through our network of 86 manufacturing sites, each year we produce nearly 4 billion packs of medicine, and we are committed to widening access to our products so that more people may benefit. A successful applicant will have an excellent practical and theoretical understanding of synthetic organic chemistry or a relevant technology and can design and execute high quality, thoughtful experimentation, while making significant contributions both independently and as a member of a team.

As a member of Drug Substance Development, you will use your chemistry knowledge and expertise to develop new chemistry routes for primary manufacture and contribute to the development and deployment of state-of-the-art processes and technologies to enable the delivery of our medicines. This is a highly practical role where you will be working in the R&D laboratories to generate new synthetic routes and process understanding that underpins the successful scale-up and commercial industrialization of GSK's future manufacturing processes. Your focus will be to combine the information generated in laboratory studies with your strong knowledge of synthetic organic chemistry to develop sustainable pharmaceutical manufacturing routes and processes.

As projects advance through development, pilot plant support may also be required across scales, culminating in the transfer of projects to our commercial manufacturing facilities around the globe. The role is highly technical and dynamic as you will be working in a number of multi-disciplinary project teams. You will thrive in this environment if you are able to effectively manage multiple priorities, communicate your recommendations clearly, and enjoy working in teams.

Key Responsibilities include, but are not limited to:
  • Designing and performing experiments in a laboratory setting to meet project timelines and objectives.
  • Thinking creatively to generate new ideas for new synthetic routes and simplifying process problems.
  • Ensuring that experimental work is communicated effectively at internal R&D meetings.
  • Participating in technology transfer activities as appropriate to our manufacturing partners Pharma Supply Chain (PSC), other parts of R&D, and partner Contract Manufacturing Organizations (CMOs).
  • Authoring or contributing to regulatory submissions, patents, scientific papers and other internal documentation relevant to the role.
  • Complying with applicable Data Integrity, Quality, cGMP and regulatory requirements in all aspects of work.


Why you?

Basic Qualifications:
  • Ph.D. in Chemistry


Preferred Qualifications:

  • Experience in multistep synthesis of complex organic molecules
  • Experience with high throughput experimentation for reaction optimization and process development activities is a plus, but not required.
  • Experience with Design of Experiments (DoE) is a plus, but not a requirement.
  • Experience in implementation of basic kinetic characterization of organic reactions is a plus, but not required.
  • Expertise in state-of-the art synthetic organic chemistry
  • Excellent problem-solving skills
  • Scientific record demonstrating excellence in chemistry (e.g., publications, patents, or presentations)
  • Experience in independent planning and execution of experiments
  • Experience in independent interpretation of data from experiments and using it to make meaningful conclusions/decisions regarding the direction of future experimentation



    Why GSK?

    At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.​



    With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.​



    Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.​

    *LI-GSK

    #LI-GSK

    #CMCDevelopmentGSK

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