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Staff Scientist - CAR T Cell Therapy

City of Hope
Duarte, California
Closing date
Sep 29, 2022

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Life Sciences, Cell Biology, Physical Sciences, Chemistry
Position Type
Full Time
Organization Type
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Job Details

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary
The T Cell Immunotherapy Program at City of Hope is a fast-paced lab involved in cutting-edge technology, research and clinical immunotherapy studies. We are currently looking for a staff scientist who will be a part of a translational science and product development team for our allogeneic iPSC CAR T project.

Key Responsibilities:
  • The scientist will be responsible for design and execution of experiments enabling development of iPSC derived CAR T product, including GMP manufacturing of human iPSC cell reprogramming, iPSC bank establishment, 3D-orgnoid culture mediated CAR T cell generation, T cell expansion etc.
  • Developing/Evaluating GMP compliant reagents, SOPs, processes and QC release assays.
  • Hands on performance and management of process development studies and research across multiple technologies including gene editing and CAR/TCR engineering on iPSC and primary T cells, iPSC directed differentiation to T cells etc.
  • Interact and collaborate with multiple teams of researchers focused on developing T cell therapies in a translational research environment.
  • This position also requires meticulous attention to detail and accuracy in lab work as well as accurate record keeping and lab documentation
  • May require weekend work

Basic education, experience and skills required for consideration:
  • Ph.D in immunology, cell biology, molecular biology, biochemistry or related field with at least 2-3 years post-doctoral research experience.
  • The PhD candidate will ideally have knowledge and experience in the fields of stem cell biology, iPSC reprogramming and directed differentiation, T cell development, immunotherapy, with demonstrated experience in cell biology and process development work.
  • Extensive experience with mammalian cell culture, preferably including iPSC maintenance and differentiation.
  • Experience in multiparameter flow cytometry, multiplex cytokine assay, gene expression profiling is highly preferred.
  • Familiarity with gene delivery approaches (viral vectors, electroporation, virus transduction) desirable.
  • Ability to effectively lead a research team to successfully meet project goals.
  • Outstanding collaborative and communication skills with diverse group of scientists involved in the product development.
  • Ability to design and execute laboratory experiments, critically interpret experimental results, and present data in a clear and concise manner.
  • Ability to participate in the preparation of grant applications and scientific publications.
  • Excellent oral and written communication skills.
  • A publication record in peer-reviewed scientific journals.

Additional Information:
See the Christine Brown, Ph.D. or Stephen Forman, M.D. web pages for an overview of research interests. For more information, please visit the CAR T Cell Therapy for Cancer website here .

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.



City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

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