Staff Scientist - Acute Myeloid Leukemia Research

City of Hope
Monrovia, California
Closing date
Dec 14, 2022

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Health Sciences, Drug Development
Position Type
Full Time
Organization Type

Job Details

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes, and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope's commitment to Diversity, Equity, and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds, and experiences to our work -- and that our teams align with the people we serve to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds, and perspectives; this is reflected in our work and represented in our people.

Position Summary

AStaff Scientistpositionin the laboratory of Dr. Guido Marcucci, Department of Hematologic Malignancies Translational Science of City of Hope,is presently being recruited.The Staff Scientist series is designed for career research professionals whose primary function is to support the research infrastructure and activities of the institution. Staff Scientists will bring special skills, knowledge,and experience to research programs or institutional core laboratories

The Marcucci laboratory studies the pathogenesis of acute myeloid leukemia (AML) and related myeloid malignancies/premalignancies and the development of new treatments for them based on these discoveries. Work in the lab utilizes both genetically engineered mouse models, patient-derived AML xenograft models, and in vitro systems. Techniques commonly used include: molecular biology, protein characterization including western blotting, flow cytometry, immunology, tissue culture, and microscopy, including the use of fluorescent probes.

The ideal candidate will have experience in cancer drug development, pharmacology, cancer immunology, flowcytometry, cell culture, mouse xenograft models, molecular biology techniques including cloning and qPCR.

Basic education, experience and skills required for consideration:
  • PhD/MDdegree in a relevant field with at least3years of experience
  • Ability to effectively lead other scientists in a translational research environment in order to successfully meetdeadlines and performand prioritize simultaneous tasks.Requires use of discretion and judgment when handling confidential information.
  • Ability to design and execute experiments, critically interpret experimental results, and present data in a cogent and meaningful manner.
  • Ability to produce first drafts of grant proposals, study protocols and manuscripts for publication of research findings.
  • Under minimal direction of the Principal Investigator, directs the work pertaining to assigned projects including supervision of technical lab staff. Responsible for the development and execution of major research projects and performs state-of-the-art, complex research projects in collaboration with researchers within the group/department and outside of the lab, making significant, original contributions including authorship or co-authorship of published findings.
  • Ensures that all laboratory activitiesare carried outin compliance with City of Hope safety, animal and human specimen use regulations.

Additional Information:

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.
  • For a complete list of Publications please visit here:
  • To Apply, please attach a cover letter describing your past training and research interests, a detailed CV and contact information of three referees

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

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