A postdoctoral fellow position is available in the Department of Cancer Biology under the direct supervision of Dr. Shabnam Shalapour. Research in the Shalapour Laboratory focuses on the role of chronic inflammation and adaptive immunity in the control of tumor development and the response of various cancers to therapy. While the focus of the research is primarily based on tumor immunology and immunotherapy, our work also addresses fundamental questions in immunology, immunometabolism, and cancer biology using cutting-edge technology tools including multicolor Flow cytometry, CyTOF, imaging, histology, and large-scale omic analysis, e.g., single-cell RNA and ATAC-seq. We aim to understand how chronic inflammation induced by obesity, aging, and alcohol abuse affects the immune system and thereby regulates its response to pathogens (bacteria and virus) and support tumor development. The focus then is on how to use this information not only to prevent cancer development but also to develop novel therapeutic approaches to increase the response to immunotherapy and vaccination (see our recent publications; Nature. 2015 May 7;521(7550):94-8, J Clin Invest. 2015 Sep;125(9), Nature. 2017 Nov 16;551(7680):340-345.; Immunity. 2019 Jul 16;51(1):15-26, Annu Rev Immunol. 2020 Apr 26;38:649-671).
This postdoc fellowship will focus on the role of adaptive immune cells, particularly B cells in tumor immunology and how chronic inflammation regulates their development and effector function, using bioinformatic tools, and genetically engineered mouse models (GEMM) and state-of-the-art immunological and experimental approaches.
Applicants must have a recent Ph.D. or M.D./Ph.D. degree in a related biomedical field with strong interests and self-motivation for research.