The University of Texas MD Anderson Cancer Center in Houston is one of the world's most respected centers focused on cancer patient care, research, education and prevention. It was named the nation's No. 1 hospital for cancer care in U.S. News & World Report's 2021-2022 rankings. It is one of the nation's original three comprehensive cancer centers designated by the National Cancer Institute.
The Sr Research Assistant will apply technical expertise and experience to plan, coordinate, design, supervise and carry out research projects in cellular signaling and drug design. Impacts cancer research efforts throughout the institution.
1. To identify the novel targets that have a synergistic effect on tumors treated with MEK inhibitors of gliomas.
2. To combine simultaneous analysis of high-throughput oncogenomic data, translational protein changes by reverse phase protein microarrays (RPPA) and functional RNAi screening to identify compensatory pathway activation and resistance to MEK inhibitors to identify the co-targets.
3. To validate the co-targets, preclinical evaluation will be achieved with the use of disease-relevant models, supported by (molecular) imaging and pharmacodynamic analysis of tumor tissue.
4. To conduct research into DNA damage Repair pathways, DNA Damage Response and Oncogenic Signaling. Our goal is to combine a basic understanding of DNA repair pathways in tumors with the development of biomarkers that predict tumor response to DNA damaging chemotherapies as well as DNA repair pathway inhibitors.
Required: Bachelor's degree in one of the natural sciences or related field.
Preferred: Master's degree in one of the natural sciences or related field.
Required: Three years of experience in scientific or experimental research work. With preferred degree, one year of required experience.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html