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Computational Scientist (Cheminformatics) Postdoctoral Fellow Drug Metabolism and Pharmacokinetics

NIH/National Center for Advancing Translational Sciences
Rockville, Maryland
Base on experience
Closing date
Nov 29, 2022

View more

Life Sciences, Analytical Chemistry
Position Type
Full Time
Job Type
PhD Fellowship
Organization Type
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NCATS, a major research component of NIH seeks applications from exceptional scientists to serve as a bioanalytic assay development for therapeutical biologics postdoctoral fellow position in the intramural laboratories of the drug metabolism and pharmacokinetics (DMPK) within the Center’s Division of Preclinical Innovation.

The DMPK Core partners with collaborators (academic institutions, foundations, and private industry) to conduct preclinical discovery and development studies leading to Investigational New Drug (IND) applications for new therapeutics. These projects play a leading role in NCATS’ mission to develop new ways to reduce, remove or bypass bottlenecks across the entire translational science continuum and address rare and neglected diseases.


Core Responsibilities

The selected candidate will work collaboratively with team members to evaluate, develop and implement bioanalytical assays to quantify therapeutical biologics and carries in blood and tissues for assigned projects. Specific duties include providing bioanalytical strategies for novel therapeutical biologics, such as peptides, conjugated peptides, mAbs, engineered human proteins, an antibody-drug conjugate (ADC), oligonucleotides, mRNAs, gene therapies, and other novel modalities.  The selected candidate also will be responsible for generating specific reagents for assay development.  The candidate will collaborate with biologists and researchers across different teams within NCATS to address project-specific needs. Additional duties include quantitatively analyzing biological samples collected from preclinical pharmacokinetic/biodistribution studies, preparing documents for regulatory filing purposes, disseminating research via peer-reviewed publications, and participating in scientific conferences and meetings.

The selected candidate should possess strong oral and written communication skills. They also should possess excellent interpersonal skills, including the ability to communicate clearly and succinctly in a timely manner. The selected candidate will be expected to demonstrate a proven ability to work collaboratively with colleagues to achieve the project, team, and organizational goals.


Applicants to this postdoctoral fellow position should possess a Ph.D. in biology, immunology, analytical chemistry, proteomics, pharmaceutical science, or a related field. A proven track record of quantitative bioanalytical method development (e.g., ligand binding assays), excellent skills to quantify active biologics in serum/plasma or tissues, and solid knowledge in the method validation and data interpretation are highly desired. Candidates with advanced knowledge and skills in HPLC-mass spectrometers, MSD, or related instruments will receive preferential consideration. Experience working on qPCR, TR-PCR, protein digestion, and immunogenicity assessment will be considered favorably. Applicants also should possess strong oral and written communication skills and be able to work in a highly collaborative team setting.


The current salary range is commensurate with experience in accordance with the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow Stipend Ranges for All Areas; health insurance benefits are available. Fellows can take part in Foundation for Advanced Education in the Sciences.

How to Apply

Please email a cover letter describing your interest in the position, including a career synopsis (one to two pages); a current curriculum vitae with a complete bibliography; and the names of and contact information for at least three references to Xin Xu, Ph.D. ( sends e-mail)). The review of applications will begin on September 1, 2022.

Additional Information

Employment is subject to the successful completion of the pre-appointment process (i.e., background investigation, verification of qualifications and job requirements, completion of onboarding forms, submission of required documents, etc.).

Due to COVID-19, NCATS currently is operating in a maximum telework state. At the discretion of the supervisor and NIH policy, you may be eligible for workplace flexibilities, which may include remote work or telework options and/or flexible work scheduling. These flexibilities may be requested in accordance with the NIH Workplace Flexibilities policy.

All information provided by candidates will remain confidential and will not be released outside the NCATS search process without a signed release from the candidates. The NIH encourages the application and nomination of qualified women, minorities, and individuals with disabilities. DHHS and NIH are Equal Opportunity Employers.




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