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Postdoctoral Research Fellow - Tumor Immunology

Lerner Research Institute, Cleveland Clinic Foundation
Cleveland, Ohio (US)
Commensurate with experience
Closing date
Sep 29, 2022

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Life Sciences, Biochemistry, Cell Biology, Immunology
Position Type
Full Time
Job Type
Postdoc Fellowship
Organization Type
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A Research Associate position is available in Dr. Li Lily Wang’s laboratory, in the department of Translational Hematology Oncology Research (THOR),  in the Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH. The Wang laboratory is engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI /CCF and the Case Comprehensive Cancer Center, affiliated with Case Western Reserve University.

Immune-checkpoint blockade (ICB) therapies have revolutionized the field of Cancer Immunotherapy. However, the low response rate in a majority of patients indicates the urgent need to identify and target additional checkpoint regulators. The Wang laboratory is among the first groups to demonstrate that the immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) is a promising target for cancer immunotherapy (1 – 6). Current projects are multi-disciplinary and involve elucidating the epigenetic and metabolic regulations by novel inhibitory receptors on tumor-associated cytotoxic T cells, tumor-associated macrophages or myeloid derived suppressor cells (MDSCs). Additional projects include investigating the mechanisms of resistance following chimeric antigen receptor (CAR) T cell-based therapies in lymphoma patients, and investigating novel immune signatures governing clinical outcomes for myeloid leukemia. These projects have a balanced basic and clinical research aspects and provide excellent training opportunities for translational researchers.

We seek talented and committed candidates with a recent PhD and with research training and experience in Biochemistry, Cell Biology, and Immunology to join our team. Interested candidates should submit CV, a statement of research interests in a cover letter, and three references to Dr. Li Lily Wang,




  1.  Le Mercier I, Chen W, Lines JL, Day M, Li J, Sergent P, Noelle RJ, Wang L (2014) VISTA regulates the development of protective anti-tumor immunity. Cancer Research, 74:1933-1944. PMC4116689
  2. Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ. (2014) Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. PNAS.  (41):14846-51 PMC4205642
  3. Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller H, Guleria I, Barth RJ, Huang YH, Wang L (2015) Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. PNAS. 112(21):6682-7, PMC4450438
  4. Xu W, Tạ MH, Malarkannan S, Wang L (2018) Review: The structure, expression, and function of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation. Cellular & Molecular Immunology. 2018 May 15(5):438-446 PMC6068175
  5. Xu W, Dong J, Zheng Y, Zhou J, Yuan Y, Ta H, Miller H, Olson M, Rajasekaran K, Ernstoff M, Wang D, Malarkannan S, Wang L (2019) Immune checkpoint protein VISTA regulates antitumor immunity by controlling myeloid cell-mediated inflammation and immunosuppression. Cancer Immunology Research  PubMed PMID:31340983; NIHMSID:NIHMS1535762






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