Post-doctoral research position in HIV pathogenesis

Employer
National Institute of Allergy and Infectious Diseases (NIAID)
Location
Bethesda, Maryland (US)
Salary
Competitive
Closing date
Oct 23, 2022

View more

Discipline
Health Sciences, AIDS/HIV
Job Type
Postdoc
Organization Type
Govt.
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Post-doctoral research position in HIV pathogenesis

A post-doctoral position is available in Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, to study cellular mechanism of HIV infection-induced host cell signaling for potential development of antiviral therapies. In particular, the lab is interested in targeting potential host genes and pathways to facilitate HIV-induced viral release. The lab recently identified L-selectin (CD62L) as a viral adhesion receptor on CD4+ T cells. The binding of viral envelope glycans to CD62L facilitates HIV entry and infection, and L-selectin expression on central memory CD4+ T cells supports their preferential infection by HIV. Upon infection, the virus downregulates L-selectin expression through shedding, resulting in an apparent loss of central memory CD4+ T cells.  Furthermore, inhibition of L-selectin shedding markedly reduces HIV-1 infection and suppresses viral release, implementing L-selectin shedding for HIV-1 release (Kononchik et al. HIV-1 Targets L-selectin for adhesion and induces its shedding for viral release. Nat Commun July 19;9(1):2825, 2018).  For more information, please refer to https://www.niaid.nih.gov/research/peter-sun-phd.

Qualified candidates should have a Ph.D. degree obtained within the past 5 years in related research fields. Interested candidates should send a letter of application and C.V. to Dr. Peter Sun, psun@niaid.nih.gov.

 

Visit NIAID Careers for more information about working in NIAID’s dynamic atmosphere!

 

HHS, NIH, and NIAID are equal opportunity employers dedicated to diversity, equity, inclusion, and accessibility.

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