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Senior Scientist, Molecular Toxicology

Groton, Connecticut
Closing date
Aug 26, 2022

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We are seeking a highly motivated and accomplished analytical scientist to join our Molecular Toxicology team in Drug Safety Research and Development (DSRD). The Molecular Toxicology team applies a variety of molecular approaches aimed at elucidating mechanisms of efficacy or toxicity, characterization of in vitro or in vivo models, understanding species differences, identifying novel translational biomarkers, and informing compound/target selection. The rapid growth of gene therapy and mRNA vaccine platforms present unique challenges that require molecular biology solutions.

The successful candidate will have a strong background in bioinformatic analysis of Next Generation Sequencing (NGS) data. These skills will be used to help to answer questions aimed at advancing Pfizer portfolio programs. As the NGS field is evolving rapidly, the candidate will also be working with a molecular biology team evaluating or developing new methods to refine existing workflows or build new capabilities for the group.

  • Analysis of various forms of NGS data (RNAseq, whole-genome sequencing, targeted panels, epigenetics, both short- and long-read sequencing), both primary analysis and downstream/pathway analysis
  • Join Computational Safety Science community and represent the Molecular Toxicology team sharing best practices, participating in project- and curriculum-based training and collaborating in analysis of large, complex datasets (e.g. single cell RNAseq, spatial transcriptomics)
  • Help to identify, evaluate, and, where applicable, implement novel methods or technologies that would provide new capabilities or enhance workflow efficiencies
  • Will apply strong problem-solving and trouble-shooting skills to a variety of molecular or cell-based techniques
  • Collaborate with colleagues on cross-functional investigative teams to investigate mechanisms of toxicity or to aid in development of predictive preclinical models
  • Effectively communicates experimental findings in both oral and written formats
  • Maintain up-to-date laboratory notebooks and records

  • BA/BS or MA/MS with 7+ years of experience in molecular biology or related field
  • Bioinformatics experience, specifically in independent analysis of NGS or other Omic data
  • R, Python or similar programming experience required
  • Contemporary knowledge of current and emerging NGS sequencing & analytical techniques
  • Experience working with multi-disciplinary teams, including generating high-quality data in a time-sensitive fashion

  • Strong analytical and programming background developing and applying novel analysis pipeline and methods
  • Experience performing basic NGS library prep and advanced sequencing techniques (e.g. single cell / single nucleus RNAseq, spatial transcriptomics)

  • Relocation Support Available

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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