Senior Research Scientist
1.Independently design, execute and interpret in vitro and in vivo experiments to validate targets, optimize compound selection and explore therapeutic potential of drug targets or other modalities.
2. Conduct in vivo antitumor efficacy or chemopreventive study using human tumor mouse xenograft, subcutaneous and orthotopic models as well as syngeneic or genetically engineered mouse models as well as maintenance of mouse colonies.
3. Develop extensive knowledge and experience in key areas of tumor biology including, but not limited to oncogenic signaling, tumor microenvironment, cancer stem cell, EMT, epigenetic deregulation or apoptosis and immune cell profiling. Design and develop cell and molecular biology assays to define mechanism of action of compounds of interest, especially single cell sequencing. Identify pharmacodynamics of natural product of interests to be used in pre-clinical and clinical evaluations.
4. Manage sample collection, biomarker analysis and data analysis of clinical specimens derived from human clinical trials conducted within the Integrative Medicine Program or other departments/programs at the institution.
5. Work closely with and instruct students, postdoc and other new laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment, and safety procedures to enhance research efforts and obtain desired results.
6.Performs other duties as required.
The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation, and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.
To plan, coordinate, design, supervise and carry out lab research projects. The primary purpose of the Senior Research Scientist position is to apply technical expertise and experiences to plan, coordinate, design, supervise and carry out preclinical research projects.
JOB SPECIFIC COMPETENCIES
Scientific and Research Project Management Serves as scientific liaison between faculty, research team, department administration and sponsor. Assist PI on their scientific endower including leading natural product discovery effort (experiment design and following up the progress of projects), writing and editing manuscripts, abstracts for scientific meetings, protocols (animal and laboratory), reports and grant proposal
Data Analysis Independently perform data analysis and properly interpret results. Analyze data generated by various studies and leverage results for the design of future studies. Effectively present results and conclusions to the PI and other collaborators.
Data Collection Manage sample collection, biomarker analysis and data analysis of clinical specimens derived from human clinical trials conducted within the Integrative Medicine Program or other departments/programs at the institution.
Other Work closely with and instruct students, postdoc and other new laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment, and safety procedures to enhance research efforts and obtain desired results. Other duties as required
Ph.D. in one of the natural sciences or related field or Medical degree. Three years of experience in experimental or scientific work. It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html