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Senior Scientist- Analytical Development, Vaccine R&D

Pearl River, New York
Closing date
Aug 23, 2022
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This is a laboratory-based analytical Senior Scientist position that reports into the Analytical Development group within Vaccine Research and Development. The successful candidate will play an important role in providing high quality, timely, critical in-process analytical support of macromolecules including nucleic acids (DNA, mRNA) and proteins to guide process development efforts. This incumbent is expected to be proficient with using and interpreting data from a range of separation and characterization techniques (e.g., LC/MS, RP-HPLC, CE, IEX, SEC/RI/MALLS, UV-Vis, CD or colorimetric based assays).


  • Identify key quality attributes for new vaccine candidates such as glycoconjugates, proteins, or mRNAs, and contribute to the selection of analytical methodology and techniques to be used.
  • Familiarity with ICH guidelines for method development, qualification and transfer to other departments.
  • Collaborate with colleagues within Vaccine Research and Development organization including Bioprocess, Analytical, and Formulation Development groups.
  • Independently analyze, interpret, and provide conclusion and present experimental data.
  • Establish and utilize new technologies, where required, to enhance our characterization toolbox and understanding about the drug substance and drug products being developed.
  • The individual will perform routine and non-routine sample analysis support for vaccine development.
  • Plan and prioritize own assay development and analysis activities to ensure timelines are met.
  • Author and review laboratory methods and reports.
  • The individual is expected to contribute and participate in general laboratory maintenance activities (such as maintenance of equipment, managing laboratory waste.


  • PhD in Chemistry, Biochemistry, or a related discipline with 0-2 years of academic, pharmaceutical, or biotechnology experience OR an MS plus a minimum of 7 years of related work experience is required
  • Demonstrated technical skills and scientific expertise in analytical method development, troubleshooting and familiarity with ICH guidelines.
  • The ability to independently design, plan, and execute method development to provide both qualitative and quantitative characterization support for early phase vaccine development programs.
  • Proficiency and ability to utilize analytical techniques such as Mass spectrometry, HPLC separation methods, CE, DLS and UV-Vis to characterize potential vaccine candidates
  • Demonstrated experience with both analytical laboratory data as well as process relevant data are a requirement to be successful in this position
  • Strong written and verbal communication skills as well as excellent documentation skills

  • Experience in the pharmaceutical industry space
  • Knowledge of biophysical techniques such as AUC, CD, DSC and ITC
  • Experience with large biomolecules (e.g. mRNA and protein) higher order characterization (HOS) characterization
  • Proficiency with R or python programming language and automation using liquid handling automation robots

  • Standard laboratory conditions - sitting, standing, primarily lab based
  • Ability to perform mathematical calculations and ability to perform complex data analysis

Work Location Assignment:On Premise

Other Job Details:

Eligible for relocation package

Eligible for employee referral bonus


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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