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Sr Computational Scientist - Genomic Medicine

University of Texas MD Anderson Cancer Center
Houston, Texas
Closing date
Oct 25, 2022

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Health Sciences
Organization Type
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The Wang Laboratory at MD Anderson Cancer Center is a computational biology research lab. We apply innovative bioinformatics approaches to deeply profile tumor cells and cells of the tumor microenvironment in order to identify tumor cell intrinsic and microenvironmental factors driving tumor phenotypic heterogeneity and evolution, and better understand the mechanisms underlying early tumorigenesis, disease progression, and the development of therapy resistance.

We are seeking a highly motivated and enthusiastic senior computational scientist who will help develop and maintain the analytical pipelines for processing and analysis of single cell and spatial multi-omics datasets. A primary responsibility of this position is to conduct bioinformatics analysis and develop novel analytical methods and tools as needed to address key biological questions.

•Participate in the design of computational experiments, data analysis and results interpretation.
• Adopt and evaluate existing methods and tools, establish and maintain computational infrastructure and analytic pipelines in the lab.
•Develop computational methods as needed for integrative analysis of single cell and spatial multiomics data.
•Conduct computational analysis of bulk, single cell and spatial multiomics data, and perform high-dimensional, multimodal data integration.
•Meets with collaborators to discuss projects and communicate results.
•Work with teams of individuals to integrate data / metadata and assist postdocs and students in the lab in analyzing and resolving analysis issues as needed.
•Assist with manuscript and grant preparation and present results during lab meetings, at department and institutional meetings and seminars, and at appropriate scientific conferences.

•Employ safe laboratory practices and help to maintain current and accurate records of research data.
•Other duties as assigned and inclusive of: attend collaborator meetings and team working group meetings; prioritize and manage multiple projects in a timely and resource-effective manner; read literatures, gather relevant information systematically, and confers with supervisor regarding new procedures; organize data on laboratory servers; Assist with data/code submission, and distribute methods and codes to the scientific community, etc.


With Inclusion, you understand that your ideas and contributions are valued. You promote the same for others. You address your own biases while promoting diversity and equity. (Competencies: Cultural Humility, Cultural Awareness, Cultural Intelligence)

With Drive, you see that you can serve as a leader whether you have a formal leadership role or not. You tackle problems, move past setbacks and hardships, and don't lose sight of your goals. (Competencies: Self-Confidence, Analytical Thinking, Innovative Thinking, Technical Expertise)

You demonstrate Professionalism by setting the example for others and consistently modeling MD Anderson's values and service standards. You communicate effectively in a variety of ways. (Competencies: Inspire Trust, Oral Communication, Written Communication)

Through Emotional Intelligence, you maintain awareness of your own emotions and the emotions of those around you. Use nonverbal cues and feelings to engage others in an inclusive and responsive way. (Competencies: Active Listening, Teaming, Self-Reflection)

Having Coachability means you are engaged in relentless learning. You constantly ask questions and stay curious. You understand that the organization constantly evolves, and you should as well. (Competencies: Develop Oneself, Adaptability)



Sedentary Environment





Wrist Motion

Occasionally 11-33%
Constant 67-100%
Occasionally 11-33%
Seldom 3-10%
Frequent 34-66%

10-20 lbs
10-20 lbs


Analytical Ability
Attention to detail
Interpersonal Skills
Oral Communication
Written Communication

Required: Bachelor's degree with a concentration in Science, Engineering or related field.

Preferred: Master's degree or PhD with a concentration in Science, Engineering or related field.

Required: Nine years of experience in scientific software programming with a concentration in scientific computing. With Master's degree, seven years experience required. With PhD, five years of experience required.

Ideal Candidate will have:
* Ph.D. degree in computer science, quantitative science, bioinformatics, biostatistics, or a related field.
* Experience in processing and analyzing single-cell multi-omics, and/or spatial omics data;
* With hree-year experience in scientific software development;
* Proficiency in at least one programming languages such as R, Python, JAVA, etc.
* Experience with Linux server administration and data management and cloud computing is required.
* Must be honest, highly motivated, reliable, responsible, well organized and a careful record keeper with good attention to details.
* Excellent written and verbal communication skills are required as well as the ability to work well in a collaborative and interdisciplinary team environment.
* Strong attention to detail, multi-tasking and a willingness to learn new technologies is encouraged.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.
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