We are looking for a talented Scientist/Senior Scientist to join the Biochemical and Cellular Pharmacology Department at Genentech. The successful candidate will be part of a dynamic and highly motivated team driving the characterization of large molecule drug candidates that are being developed for various diseases in the neuroscience therapeutic area.
You will be responsible for the development, optimization and execution of functional pharmacology assays especially utilizing complex cellular or engineered organoid/tissue models to support our oligonucleotide therapeutics discovery programs for the selection and advancement of lead molecules for various diseases in the neuroscience therapeutic area.
This position requires working with multidisciplinary teams, including biology team members from Discovery Research, as well as with Antibody Engineering, Protein Chemistry, Structural Biology, Pharmacokinetics and Safety Assessment. You are expected to represent Biochemical and Cellular Pharmacology on project teams and contribute at the bench as well as at strategic levels. A strong candidate will be enthusiastic about supporting the operation of a dynamic laboratory, have great attention to detail and superior organizational skills. Working with automation and bioinformatics experts, the individual will be expected to implement robust and high throughput sample preparation as well as data analysis workflows. You will have the opportunity to design and execute complex screening cascades for multiple projects, conduct detailed data analyses and present these to project teams and senior management. Supervise and manage third-party and CROs for external collaboration and outsourced work as needed.
- Ph.D. in molecular and cellular biology, neuroscience or a related field.
- Minimum of three years postdoctoral/pharma experience with strong record of high-profile publications.
- This position requires prior experience with oligonucleotide therapeutics in drug discovery.
- Hands on experience with human induced pluripotent stem cells (hiPSCs). Differentiation of hiPSCs to various cell types for the aim of disease modeling and drug discovery. Demonstrate experience with CRISPR gene editing in hiPSCs.
- Ability to adopt and leverage rapidly advancing, new technologies to promote strategic aims.
- Excellent teamwork, communication, time management, interpersonal skills and ability to work independently.
- Focus on quantitative methods to drive results, and demonstrate resilience and persistence in their experimental approach.
- Familiarity with automated or semi-automated instrumentation, while not required, would be advantageous.
- Experience with in vitro drug screening.
- Hands on working knowledge of oligonucleotide therapeutics discovery and in vitro assays.
- Experience with hiPSC differentiated cell models for screening
- Previous pharmaceutical/biotech experience in relevant models.
Relocation benefits are available for this position
Who We Are
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.
Who We Are?
Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.
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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.
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