Research Associate - Computational Biology in 3D Genomics

Summary

The lab of Dr. Kyle Eagen ( www.eagenlab.org ) at Baylor College of Medicine focuses on elucidating how DNA folds within cells and how DNA misfolding relates to human disease. Baylor College of Medicine is well known for its exceptional, innovative, and collaborative research environment. It is investing significant resources in expanding interdisciplinary research in the molecular, cellular, biochemical, and genetic bases of human health and disease. Dr. Eagen's lab is dedicated to state-of-the-art molecular research using interdisciplinary approaches and the newest technologies while fostering career development and advancement. The lab is located in the Texas Medical Center, the largest biomedical complex in the world, immediately adjacent to Houston's vibrant Museum District and Hermann Park.

A Research Associate position is available in the laboratory of Dr. Kyle Eagen in the Department of Molecular and Cellular Biology. The Research Associate will expand upon a dynamic research program dedicated to understanding the molecular basis of nuclear organization and 3D genome architecture. They will be responsible for taking on highly interdisciplinary projects and critical functions in this endeavor using tools from molecular biology, biochemistry, cell biology, and genomics, including next-generation DNA sequencing technology. In addition, they will work side-by-side with Dr. Eagen to develop advanced scientific skills alongside opportunities to present research findings at conferences and network with colleagues.

The ideal candidate should be highly motivated, well organized, manage time effectively, and be able to work independently as well as part of a team. They will obtain fundamental, career-building exposure in genomics, molecular biology, cell biology, and biochemistry as they conduct lab research and assist in leading and designing projects.

Job Duties

• Design, set up, conduct, and troubleshoot experiments.
• Evaluate experimental results and recommend changes to improve data quality and validity.
• Complete mathematical calculations to assist in data analysis.
• Apply advanced skillset to research projects:
  • Molecular Biology
    • Isolate and purify DNA, RNA, and/or protein
    • Perform PCR and prepare plasmids
    • Clone and sequence DNA
  • Cellular Biology
    • Cell culture, transfection, and transgene expression
    • CRISPR/Cas9 gene editing
    • Functional studies
• Administrative
  • Maintain detailed records of research experiments and data
  • Prepare charts and graphs for presentations and publications
  • Search and evaluate scientific literature in support of research projects
  • Write portions of grant applications, manuscripts, and publications
  • Co-author scientific papers
• Effectively interact with team members to make important contributions on big problems while ensuring high scientific standards

Minimum Qualifications

• Master's degree in Basic Science or a related field. Experience in lieu of degree will not be accepted.
• Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.

Preferred Qualifications

• Experience in molecular biology and genomics techniques, such as Hi-C, ChIP-seq, CUT&RUN, and/or RNA-seq
• Experience in cell biology, such as cell culture and/or CRISPR/Cas9 genome editing
• Demonstrated ability to learn new technologies
• Outstanding interpersonal and communication skills and the ability to work independently and in a team environment
• A record of taking initiative to solve problems and working to high-quality standards
• Attention to detail and accurate record keeping
• Ability to multitask, work and learn independently, and be self-motivated
  

Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

12721

CA; SN