Pfizer's Centers for Therapeutic Innovation (CTI) is a pioneering research unit that partners with leading academic medical centers and disease foundations to translate novel breakthroughs into therapies that change patients' lives. CTI laboratories in Manhattan, Cambridge, San Francisco and La Jolla are assembling a cross-disciplinary team of Post-Doctoral Fellows to explore and identify RNA medicine approaches in the integrated space of cellular reprogramming, mRNA, epigenetics, gene editing, immunology/inflammation and oncology. This is a unique opportunity for a driven, exceptional PhD-level scientist to leverage their expertise and develop their scientific acumen & drug discovery skills while collaborating with multidisciplinary research teams at Pfizer and academic subject-matter experts.
The Post-Doctoral Fellow will be a member of the Pfizer RNA Medicines group in CTI. They will work collaboratively with biology teams, portfolio project teams and other post-docs to further our understanding of cell lineage in the context of immune and other responses to RNA Medicines. While performing independent, cutting-edge research, the Post-Doctoral Fellow will join forces with experienced drug hunters, colleagues focusing on target identification and validation, hit discovery, as well as pre-clinical animal studies and safety, with the goal of making clinically-relevant, groundbreaking discoveries and publishing in high-impact journals.ROLE RESPONSIBILITIES
QUALIFICATIONS BASIC QUALIFICATIONS
- Demonstrate deep scientific and technical expertise harnessed to advance our understanding around how cell lineage impacts immunological and other responses to RNA medicines to ultimately improve and refine RNA modalities.
- Independently design and test biological hypotheses, while also leveraging the breadth of expertise available from other Postdoctoral Fellows and subject matter experts across Pfizer and the external academic collaborative network.
- Execute targeted in vitro and in vivo experiments, while leveraging state of the art technologies and resources to address fundamental questions regarding cancer drug resistance mechanisms that can uncover novel therapeutic angles in this space.
- Generate, organize, analyze, interpret data, and identify areas where key knowledge is lacking. Proactively seek new scientific leads via genetics & AI-based resources, literature, conferences and key opinion leaders with the goal of refining scientific hypothesis and expediting experimental plans.
- Effectively communicate results at internal and external events and proactively contribute to the continued scientific growth at Pfizer.
- Contribute to a culture that embraces scientific excellence, effectiveness, and team-work.
- Recent Ph.D. in molecular and cell biology, rare disease, cancer biology, immuno-oncology, immunology, or a related field, with a strong track record of scientific publications.
- Significant expertise with an array of molecular and cell biological techniques, including QPCR/Nanostring, MSD, mRNA IVT, transfection protocols, primary cell tissue culture and assays (human PBMCs, etc), multi-color flow cytometry and/or bioinformatics analysis.
- Must have excellent organizational and planning skills, and the motivation and ability to work in a fast-paced environment independently and as part of a team.
- Excellent verbal and written communication skills. Ability to quickly master new concepts and techniques.
OTHER JOB DETAILS
- Direct experience with mRNA delivery, gene editing, gene insertion, transcriptional regulation of cell programs, innate immunity and /or cancer biology
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Research and Development