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Sr. Computational Geneticist

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Closing date
Aug 16, 2022

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Discipline
Life Sciences, Computational Biology, Genetics
Position Type
Full Time
Organization Type
Pharma
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ROLE SUMMARY

Human genetics has become an increasingly important and routinely applied tool in biology-led therapeutic development, including in immune and inflammatory diseases. The value of genetic evidence is seen in all aspects of target discovery, validation, and drug development. The Systems Immunology group in the Inflammation & Immunology Research Unit at Pfizer seeks to continuously expand the scale, complexity, and translatability of genetics and multi-omics in support of our drug discovery goals.

We are seeking an experienced human geneticist to join our efforts to translate genetic findings into therapeutic hypotheses and mechanistic insight for drug development, by
  • Identifying and validating therapeutic targets with genetic evidence;
  • Identifying genetic predictors and biomarkers of disease risk, disease state, heterogeneity, and therapeutic response; and,
  • Elucidating the functional consequences of genetic variants using disease-relevant molecular and cellular models.


ROLE RESPONSIBILITIES
  • Conduct genetic analyses to identify and interpret genetic drivers of diseases and phenotypes, using established analytical approaches and computational tools. Devise or modify analytical methods where appropriate.
  • Interact with multidisciplinary project teams as the genetics subject-matter expert; devise genetic solutions and apply findings to answer questions in the drug development process.
  • Work closely with colleagues in Systems Immunology and the Pfizer Integrative Biology community to establish and apply computational genetics tools; and to bridge genetics with multi-omics and functional genomics, to solve drug discovery challenges.
  • Participate and/or lead in external public and/private collaborations and consortia.


BASIC QUALIFICATIONS
  • PhD. or MD/PhD with with thesis research in Genetics, Genomics, Immunology, Biology, Statistics, or related fields.
  • 0-3 years post-graduate work experience in an academic or biopharma/biotech setting.
  • Expertise in computational population and medical genetics approaches including association analyses, Mendelian randomization, fine-mapping, and genetic architecture of complex traits, etc.
  • Experience in following up on genetics findings to explore functional consequences of genetic variants by integrating human genetics with multi-omics data types including transcriptomics, proteomics, and epigenetics, as well as functional genomics.
  • Demonstrated track record of excellence in publications.
  • Proficiency in scripting languages such as R or python.
  • Excellent communication skills, including presentation of computational research approaches and results to multidisciplinary teams.


PREFERRED QUALIFICATIONS
  • Training or in-depth research experience in human biology, immunology, physiology and/or medicine.
  • Working knowledge in the pathophysiology and/or genetic pathoetiology of autoimmune & inflammatory diseases.
  • Experience in a pharmaceutical or biotech setting and familiarity with the drug discovery process.


PHYSICAL/MENTAL REQUIREMENTS

Office-based role.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Occasional travel.
\nRelocation support available\n
Work Location Assignment: Flexible

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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