Skip to main content

This job has expired

Postdoctoral Associate- Cancer Biology and Epigenetics

Employer
Baylor College of Medicine
Location
Houston, Texas
Closing date
Oct 28, 2022

View more

Discipline
Life Sciences, Biology, Cancer Research, Epigenetics
Position Type
Full Time
Job Type
Postdoc
Organization Type
Academia
Summary

A postdoctoral position is immediately available in the Barbieri laboratory to study the molecular mechanisms regulating tumor initiation and progression in neuroblastoma, a pediatric cancer arising from sympatho-adrenal neural crest cells. The lab aims at understanding how MYCN drives undifferentiated, chemo-refractory, and metabolically distinct tumors, and developing novel approaches to intervention for high-risk MYCN-amplified neuroblastoma. Specifically, the lab is focused on the study of how MYCN interacts with specific epigenetic factors - such as CHAF1A - to drive oncogenesis, with particular emphasis on epigenetics, transcriptional regulation, cell differentiation and metabolism (Moreno-Smith et al. Nature Communications 2021; Tao et al. Advanced Science 2021; Tao et al. Nature Communications 2022). The candidate will use a combination of various cell and molecular biology approaches (including CRISPR-Cas9 gene editing, ChIP-seq, RNA-seq, ATAC-seq, metabolomics and metabolic tracing), as well as different tumors models (transgenic, xenograft/PDX and syngeneic) and neural crest models to elucidate the epigenetic changes induced by MYCN and CHAF1A during neuroblastoma initiation and progression.

Job Duties

  • Designs and performs experimental studies that directly answer the above research questions, using both in vitro systems and animal models.
  • Collects and analyzes data to present at national/international meetings.
  • Prepares manuscripts for publication.
  • Applies for external fellowships.
  • Mentors junior lab members.


Minimum Qualifications

  • MD or Ph.D. in Basic Science, Health Science, or a related field.
  • No experience required.


Preferred Qualifications

  • Prior first author publications.
  • Strong background in cancer biology, epigenetics, cell and molecular biology, mouse models of cancer, and cancer cell metabolism.
  • Candidates should be highly motivated to pursue an independent career in biomedical research.


Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

12575

PD; CA; SN

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert