Senior Research Technician, Mass Spectrometry - Kajimura Lab

We are seeking a Senior Research Technician, Mass Spectrometry with expertise in mass spectrometry to join the lab of Dr. Shingo Kajimura at Beth Israel Deaconess Medical Center. The Kajimura Lab focuses on the molecular mechanisms of bioenergetics.  We apply the most cutting-edge technologies and multidisciplinary approaches to generate a blueprint for reprogramming regulatory circuits of adaptive responses by defined factors.  Our research leads to new therapeutic interventions for the treatment of metabolic disorders (obesity, diabetes), cancer, and aging. To learn more about the lab, visit their website.

This position will have you serving as a lynchpin member of the lab, and allow you to collaborate closely with group members to run samples in support of varied research throughout the lab. The ideal candidate should have ample hands-on experience independently operating and maintaining LC-MS instrumentation with a proven track record of full scan analysis, targeted measurements, and quantitation in complex biological samples. The primary instrument in our lab is a Thermo Orbitrap Exploris Mass Spectrometer.

This is a rare opportunity to be a part of a dynamic and highly collaborative research team, with excellent benefits and the opportunity to work on truly cutting edge research.

In this role you will:

• Independently provide regular maintenance for our LC-MS instrument.

  • Interact with technical  support for the devices to perform preventative maintenance and address any technical issues that arise.

• Interact closely with lab members to plan and perform experiments at every stage from sample collection and preparation to data collection.

• Efficiently organize lab use of LC-MS to optimize throughput of samples.

• Process LC-MS data and share results with relevant team members.

• Contribute to preparation of manuscripts, grants and scientific presentations.

• Train lab members on aspects of our analytical pipeline (sample preparation, running the instruments, etc)

• Participate in weekly laboratory meetings and planning sessions.

Skills and experience you bring:

• Prior experience in analytical chemistry with strong practical and theoretical expertise in  LC-MS including separations techniques.

  • Bachelor’s degree in chemistry, biochemistry, or biology or related field required

• Prior experience working with Thermo LC-MS instrument is a plus, but not required.

• Proven track record of LC-MS application to metabolomics and stable isotope tracer experiments.

• Proficiency with data acquisition and analysis software (such as TraceFinder, Compound Discoverer).

• Excellent oral and written communication skills to interact with colleagues and technical support.

• The ability to operate instrumentation with reliability and accuracy, with minimal supervision.

• Excellent organizational, communication and time management skills.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, contamination by toxic chemicals and acids and presence of carcinogenic substances.

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.  Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.

Compensation and Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more. 

HHMI is an Equal Opportunity Employer