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Principal Scientist, Translational Sciences Immune Cell Engagers

La Jolla, California
Closing date
Jul 10, 2022

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Life Sciences, Cell Biology, Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

You will join a dynamic team of scientists in our Translational Sciences Immune Cell Engagers Group and play a leading role in guiding project teams in the appropriate planning and use of cancer models to evaluate new drug candidates, mechanisms and targets.

As the In Vivo Lead, you will participate in pre-clinical drug discovery and development projects with a focus on immune cell engagers, while also contributing to projects related to immuno-oncology, signal transduction, targeted therapeutics, and epigenetics. You will be responsible for working with project teams to design, plan and execute an in vivo strategy to ensure efficient and effective decision-making. You will also be a key contributor to the In Vivo Committee, present study plans and obtain peer input for protocol finalization and approval to meet research project objectives.

You will lead a small team of scientists and coordinate and oversee the work of other scientists with accountability for study performance and data analysis.

You will provide technical and scientific expertise in in vivo pharmacology across Oncology Research and Development to enable target identification, validation, prioritization and efficient drug discovery.

How You Will Achieve It

  • Establish scientific in vivo strategy and study plans for drug discovery projects
  • Serve as the in vivo pharmacology lead for several drug discovery projects. Ensure that projects have all critical in vivo data to enable project stage dependent decisions.
  • Work within multi-functional teams to support target identification, validation, drug discovery and combination therapy.
  • Work across in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across Translational Pharmacology.
  • Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
  • Develop and characterize new in vivo mouse models, including syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies.
  • Ensure team members comply with all regulatory requirements and internal policies.
  • Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize value of the contribution by the in vivo team.
  • Interpretation, presentation and documentation of experiments as well as preparation of reports. Written and verbal presentation of results within a multidisciplinary team environment.
  • Responsible for contribution to relevant in vivo sections of study reports and regulatory documents i.e. IND filings.
  • Supervision and guidance of reports.
  • Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.


  • Ph.D. in Cancer Biology, Immunology, Biochemistry, Genetics or a related discipline and 5 years post doc and/or industry experience
  • Specific experience in macrophage and NK cell biology
  • Experience in the application of immune cell redirecting platforms (e.g. CAR-T, BITEs, bispecific antibodies) and assessment with appropriate in vivo modelling / PD and biomarker readouts
  • Experience in collaborative research in Oncology drug discovery programs
  • Hands on experience with animal models of human cancers
  • Strong publication record or evidence of equivalent achievements in industry
  • Experience with GEMM and humanized models

  • Hands on in vivo (eg: IV, PO dosing, blood/tissue collection) and ex vivo skills (flow cytometry, western blot, ELISA)

  • Excellent written and oral communication and presentation skills.

  • Proficiency in all common office and scientific software

  • Must be willing and able to work after hours as needed to ensure study integrity
  • Supervisory experience is a significant plus


Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.


Must be willing and able to work after hours as needed to ensure study integrity.

Relocation support available

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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