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Post Doc (Predictive Product Design)

Collegeville, Pennsylvania
Closing date
Jul 8, 2022

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The Post doc, Predictive Product Design, will be part of a team developing advanced mathematical modeling approaches for understanding product performance and manufacturing processes for sterile & biopharm drug products to accelerate development, increase fundamental mechanistic understanding, and deliver more robust product design. This involves adopting a “predict first” approach through the development of mechanistic, empirical, and hybrid modeling methodologies to support product design and development.

Working in a dynamic, multidisciplinary environment, the successful candidate will develop, calibrate, and use engineering, biopharmaceutics, chemical and materials science knowledge to develop system models to enhance the mechanistic understanding of manufacturing processes, and in vivo product performance (PK). This position is an exciting opportunity to make a positive difference in the lives of patients by focusing on the right product design through a “predict first” approach.


This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include the following:
  • As part of matrix project teams, develop system models for process and product performance for sterile and biopharm drug products.
  • Use engineering, chemical, biological and materials science knowledge to postulate mechanisms for physicochemical and biological processes and develop and / or modify existing mathematical models to describes those mechanisms.
  • Stay current with new modeling techniques through publications, conferences, and academic and precompetitive collaborations.
  • Further evolve modeling approaches for maximizing the positive impact on projects.
  • Peer review modeling work from colleagues as appropriate, ensuring high quality standards for the modeling work.
  • Promote and increase the reputation of the modeling internally within R&D and externally.
  • Track progress against deliverables and maintain a communication plan with stakeholders and partners across departments.
  • Advocate and comply with GMP requirements for recording experiments and associated data, and writing reports, including scientific review and data checking.
  • Comply with the requirements of Quality, Safety, and GSK policies and procedures and ensure that GSK intellectual property is protected.

Why you?

Basic Qualifications:

  • Ph.D. in chemical, mechanical or biomedical engineering, physics, applied mathematics, scientific computing, or related field

Preferred Qualifications:

  • Familiarity with the challenges of drug discovery and forward thinking with respect to the general application of mathematical models in discovery and development
  • Experience in identifying, developing, and applying innovative solutions to scientific and technological problems faced in systems modeling
  • Knowledge and understanding of drug delivery, absorption, distribution and metabolism, pharmacology and toxicology, PK/PD modeling, physiological based modeling (PBPK) and translational sciences
  • Experience in mechanism based mathematical modeling techniques
  • Experience in building, validating, and using complex, system level models of biological and chemical systems
  • Core competency in numerical analysis focusing on differential equations and parameter optimization
  • Working knowledge of statistical and machine knowledge approaches
  • Experience translating mathematical models into computer programs using Matlab, SimBiology, Python, or similar software tools
  • Scientific curiosity and demonstrated ability to learn
  • Excellent written and oral communication skills and the ability to interact effectively with scientists in other disciplines with a positive, collegial, collaborative attitude

Why GSK?

At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.​

With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.​

Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.​



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