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Investigative Pathology Scientist, Digital Image Analysis

Cambridge, Massachusetts, United States;Groton, Connecticut, United States;
Closing date
Jul 8, 2022

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What You Will Achieve

This position will reside within the Global Pathology (GP) group in Drug Safety R&D (DSRD). Digital pathology is a new field with tremendous growth opportunities and is of strategic interest to DSRD GP. We are seeking a motivated Scientist to perform whole-slide, digital image analysis (DIA) to quantify protein and nucleic acid targets that have been labeled in tissue sections using immunohistochemistry (IHC) and in situ hybridization (ISH) methods, respectively.

The ideal candidate will have experience quantifying targets labeled using immunofluorescence (IF) approaches, including multiplex IF, and will also have hands-on experience using machine learning (ML) and deep learning (DL) tools to create algorithms to quantify morphological features in histopathological images or to supplement conventional DIA methods. Responsibilities will include scanning glass slides using whole slide digital scanning instruments. The candidate must be able to work independently and collaborate with GP team members, while having strong organizational and communication skills to foster effective collaborations with pathologists and research unit (RU) scientists on project teams.

This position is site agnostic, and may be located in La Jolla CA, Groton CT, or Cambridge MA.

How You Will Achieve It
  • Run established DIA algorithms using commercial and open-source image analysis software packages to quantify target expression in support of investigative studies
  • Develop custom ML/DL DIA algorithms to support portfolio studies using commercial image analysis software
  • Independently analyze and interpret the data, perform statistical analysis of DIA endpoints, generate reports for internal teams and complete the studies in a timely manner
  • Present data to key project stakeholders within and outside of the organization
  • Perform whole-slide scanning of glass microscope slides into a virtual image archive using digital scanners
  • Follow established operating procedures, maintain electronic/paper lab notebooks and imaging data and QC documents
  • Perform all regulatory responsibilities in compliance with applicable regulatory standards including Good Laboratory Practices and animal welfare regulations


  • Bachelor's Degree in Biology, Biotechnology, Biomedical Engineering, or related field with minimum 4 years of relevant DIA experience OR Master's degree with minimum 2 years of relevant DIA experience.
  • Experience using one or more image analysis software packages, such as Visiopharm, HALO, inForm, Definiens, QuPath or Cell-Profiler.
  • 2 years of programming experience in any of the following languages: MATLAB, C/C++, Python or R.
  • Excellent written and oral communication skills.
  • Ability to interact, contribute, and communicate effectively with the team.

  • Experience using commercial ML/DL modules to supplement DIA algorithm development.
  • Experience with DIA of multiplex IF or IHC assays.
  • Experience with developing AI/DL algorithms using Python/R.
  • Image processing domain knowledge: segmentation, classification, feature selection/extraction.
  • Experience with whole slide scanning process and instruments (Leica AT2 and GT450, Zeiss Axioscan).

  • All candidates with suitable technical experience will be considered.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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