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Senior Scientist - Protein Engineering & Biotherapeutic Discovery

La Jolla, California
Closing date
Jul 8, 2022

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Physical Sciences, Chemistry, Engineering
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

What You Will Achieve

Pfizer's Biotherapeutic Discovery group in La Jolla is seeking an outstanding and highly motivated Senior Scientist to be part of the protein engineering group supporting our biotherapeutics portfolio. Working with the team, you will be responsible for discovery and optimization campaigns on new therapeutics using Pfizer's display libraries. You will use your protein engineering expertise and be responsible for extensive molecular biology of various constructs. You will also contribute to protein expression and purification, as well as development of new cell-based assays. You will have access to state-of-the-art engineering technologies and advanced automation equipment. With your deep knowledge in the discipline, you will be an active team member who influences at the project team level. Your creativity in developing novel processes and new ideas will be used frequently.

How You Will Achieve It

  • You will work with the team on discovery of new biotherapeutics by combining your knowledge of the protein scaffolds, surface display technologies and rational optimization techniques
  • You will help design workflows and conduct experiments for therapeutics' discovery and optimization
  • You will use high-throughput molecular biology methods such as reformatting scFv to IgG, designing and building new libraries, or designing nucleic acid constructs
  • You will express and purify various protein scaffolds and develop new cell-based assays
  • You will use state-of-the-art automation equipment for screening promising antibody clones
  • You will be a part of multidisciplinary and cross-functional teams to develop next generation therapeutics
  • You will be responsible for bookkeeping and presentation of results at internal meetings
  • You will be working on multiple projects in parallel to ensure timely delivery of potential therapeutic leads


  • PhD in Biological Sciences (Molecular Biology, Structural Biology, Protein Biochemistry, Cell Biology) or a related field (Chemical Engineering, Biomedical Engineering and Biological Engineering)
  • MS with 7+ years biotechnology/pharma experience, or BS with 10+ years of biotechnology/pharma experience
  • Extensive experience with using molecular biology
  • Experience with protein purification techniques
  • Knowledge of antibodies and display technologies such as phage/ yeast and/ or ribosome display and experience with DNA and mRNA
  • Experience with mammalian cell culture
  • Track record of demonstrating analytical skills, bench skills and problem-solving skills
  • Ability to maintain very detailed experimental documentation
  • Understanding the underlying principles of the performed experiments
  • Outstanding pro-active attitude, interpersonal, collaborative and oral communication skills
  • Ability to work in an interdisciplinary scientific team and the desire to learn new techniques
  • Good communication skills and ability to present research in a team setting
  • Strong time management skills and ability to manage multiple projects in parallel

  • Previous experience with phage/ yeast and/or ribosome display
  • Previous experience with protein engineering of antibody and non-antibody scaffolds
  • Previous experience with development of cell assays and work with nucleic acids
  • Previous experience with automation
  • Previous experience with high throughput screening methods
  • Understanding structure-function relationship for design of protein molecules

Other Job Details

Relocation Support Available
Work Location Assignment:On Premise

Last Day to Apply: July 15, 2022

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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