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Senior Scientist, Translational Sciences Immune Cell Engagers

La Jolla, California
Closing date
Jul 7, 2022

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Life Sciences, Cell Biology, Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

You will join a dynamic team of scientists in our Translational Sciences Immune Cell Engagers Group and play a leading role in using models of cancer to evaluate new drug candidates, mechanisms and targets.

You will participate in pre-clinical drug discovery and development projects with a focus on immune cell engagers, while also contributing to projects related to immuno-oncology, signal transduction, targeted therapeutics, and epigenetics. You will characterize and develop large and small molecules in close collaboration with partner lines as an integral member of drug discovery teams. You will employ and develop new cutting-edge in vivo mouse and human cancer models. You will provide technical and scientific expertise in in vivo pharmacology to the immune cell engaging teams to enable target identification, validation, prioritization and efficient drug discovery.

How You Will Achieve It

  • Work within multi-functional teams to support large and small molecule drug discovery and combination therapy.
  • Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
  • Interpretation, presentation and documentation of experiments within an electronic lab notebook, as well as preparation of reports.
  • Written and verbal presentation of results within a multidisciplinary team environment.
  • Develop and characterize new in vivo mouse models, including syngeneic tumor, genetically engineered mouse (GEM) models and humanized mouse models, to study biologic mechanisms and support exploration of novel therapies.
  • Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.


  • Ph.D. in Cancer Biology, Immunology or in a similar discipline with a minimum of 1 year post doc or industry experience or a related MS and a minimum of 7 years relevant industry experience
  • Hands on experience with in vivo pharmacology and experience with animal models of human cancers
  • Experience in macrophage and NK cell biology
  • Experience in the application of immune cell redirecting platforms (e.g. CAR-T, BITEs, bispecific antibodies) and assessment with appropriate in vivo modelling / PD and biomarker readouts
  • Hands on experience with GEMM and humanized models highly desirable.
  • Hands on in vivo experience (e.g.: IV, PO dosing, blood/tissue collection, tumor implantation) and ex vivo skills (flow cytometry, western blot, ELISA).
  • Current knowledge of oncology research, drug discovery and development, with emphasis on drug combinations, immuno-oncology.
  • Excellent written and oral communication and presentation skills .
  • Experience multi-tasking and workin productively in a fast-paced, highly collaborative, and diverse team environment.


Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.


Must be willing and able to work after hours as needed to ensure study integrity.

Relocation support available

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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