Histology at GSK
At our world-class scientific hub in Upper Providence, US, our Non-Clinical Histology department currently has an exciting career opportunity for a talented Molecular Investigator/Histologist with a passion for science, multi-discipline integration, and applying their skill set to addressing human disease. We understand that the fewer barriers there are, the better our work can be. That is why we encourage an enterprising and highly collaborative approach to Discovery projects and Pre-Clinical programs.Key Responsibilities include, but are not limited to:
- Supporting the use of digital whole slide scanning and the application of image analysis algorithms using commercially available platforms (e.g. HALO, Visiopharm). Apply advanced data analysis and visualisation methods (Spotfire, Cytobank, Graph Pad etc) to deliver maximum impact from non-clinical histology data.
- Manual and automated platform optimisation/validation of IHC/IF antibody clones, dilutions, antigen retrieval and signal amplification technologies on both cryo and paraffin embedded human and animal tissues.
- Optimisation of ISH probe assays on both human and animal tissues. Developing & delivering low (2-6 plex) number multiplex immunohistochemistry/Immunofluorescence (IHC/IF), in situ hybridization (ISH) and co-localisation IHC/ISH protocols in support of Non-Clinical histology.
- Applying existing molecular histology techniques (proteomics, qPCR and RT-PCR) alongside IHC/IF & ISH in frozen and formalin fixed paraffin embedded human and animal tissues as part of antibody/ISH probe optimisation & validation.
- Maintaining timely communication to named key study personnel, other key stakeholders and management, of study related events and/or deviations.
- Working collaboratively with Discovery pathologists to identify project needs and develop tissue-based experiments to address project questions by agreed timelines.
- Working in partnership with project teams to understand project issues, provide input and report data to matrix teams, including close networking with all imaging groups across GSK. Apply broad knowledge of science, drug discovery and histology/ molecular assays to guide experimental designs that deliver the best possible science.
- Adopting and routinely apply other tissue-based assay technologies as they become embedded within the histology community.
- Presenting data to represent non-clinical histology/Bioimaging in internal and external scientific seminars and publish scientific papers where appropriate.
- Where needed due to study size, provide additional necropsy support on a range of animal species and strains, including non-standard study designs, and provide accurate recording of necropsy data including macroscopic findings.
- Sharing responsibility for lab management, equipment maintenance, safety rep and similar roles
We are looking for professionals with these required skills to achieve our goals:
- BS/MSc. in a Biological Science or related discipline with experience in academia or pharmaceutical/biotech/CRO organisation
- Require HT/HTL certification from ASCP.
- Extensive experience in IHC/ISH/IF assays optimisation both manually and with automated platforms
- Ability to work both independently and collaboratively, and to handle several concurrent, fast-paced projects.
- Demonstrated Digital pathology expertise in tissue & cell based Image analysis using commercially available platforms/software
If you have the following characteristics, it would be a plus:
- PhD in Biomedical sciences, cellular pathology, biology, biochemistry or immunology.
- QIHC certification is preferred
- Experience in sample cut-up, fixation/freezing, biobanking, documentation and sample QC, including ensuring compliance with the GSK policy on human sample.
- Necropsy experience is preferred.
- Good biological knowledge of oncology, respiratory and inflammatory disease human and animal models would be an advantage.
At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:
New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.
With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.
Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients
- so we deliver what matters better and faster;accountable for impact
- with clear ownership ofgoals and support to succeed; andwhere we do the right thing
. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.
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