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Investigator, Bioimaging (Collegeville, PA)

Collegeville, Pennsylvania
Closing date
Jun 28, 2022

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Other, Other
Job Type
Group Leader/Principal Investigator
Organization Type
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Investigator, Bioimaging

GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

We have an exciting new position available within the Bioimaging team at GSK, based at our world-class R&D site in Collegeville, PA. The role will focus on development of targeted and non-targeted optical and mass spectrometry-based imaging workflows to advance our project decision making based on spatial drug distribution and functional pharmacology mechanistic endpoints. As part of the Bioimaging team, you'll be responsible for the application and advancement of imaging mass spectrometry (IMS) to better understand the mechanisms of drug tissue disposition, pharmacokinetics, pharmacology, and toxicology in the development of safe and efficacious drugs. Utilizing leading edge MS instrumentation, custom imaging software tools, and pioneering IMS tissue quantification, our innovative group works collaboratively to help drive critical decisions supporting the advancement of novel medicines. Building on the established spatial drug distribution workflow, complementary imaging approaches are being applied to define the detailed tissue architectures and cellular microenvironments to contextualize the pharmacological outcome. The successful candidate will join a highly collaborative and motivated team of scientists focused on providing innovative solutions to help deliver safe and efficacious new medicines to patients.

Bioimaging at GSK

The Bioimaging department brings together key areas of in vivo and ex vivo imaging combined with histology to understand both disease state and intervention, combining data on drug distribution with the effect that distribution has on intact biological systems. At GSK we believe that the fewer barriers there are in delivering the science, then the better our delivery of new medicines to patients. As part of the wider In Vitro/In Vivo Translation platform we encourage enterprise collaboration as well as external partnership with the wider scientific community to achieve our full potential.

Key Responsibilities:
  • Responsible for the design, facilitation, and delivery of targeted and non-targeted MALDI IMS experiments including preparation, acquisition and data analysis to support multiple programs.
  • Responsible for generating and integrating spatial omics data to measure spatial biology, contextualize drug distribution, and discover pharmacodynamic biomarkers
  • Work together with matrix teams to propose and deliver potential solutions to key project issues including networking with other groups across GSK.
  • Effectively analyze and interpret IMS data for presentation to project teams.
  • Through collaboration with imaging and non-imaging colleagues, integrate IMS data with other methodologies as part of a multi-modal approach to drive critical project decisions.
  • Further the development of both quantitative and non-targeted IMS workflows to improve upon the impact and efficiency of acquisition and data processing strategies.
  • Support the upkeep and maintenance of lab instrumentation.

Basic qualifications:
  • PhD in Chemistry, Biology, Physical Sciences, or related discipline with a focus on the drug-discovery process.
  • Experience with generating spatial transcriptomics, proteomics, and/or metabolomics data.
  • Experience with troubleshooting and maintaining complex instrumentation.
  • Knowledge of visualization, statistics, and bioinformatic strategies.
  • Established track record of continued scientific contributions through presentations and publications.

Preferred Qualifications:
  • Hands-on experience with Bruker mass spectrometers including Solarix/SciMax and Rapiflex systems.
  • Evidence of effective, collaborative interpersonal, organizational and communication skills, both oral and written, for working in a multi-disciplinary scientific team environment.

Why GSK?

At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.​

With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.​

Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.​


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