The Viral Vaccines department is seeking an energetic graduate with interest in vaccine development. The incumbent is responsible for supporting the preclinical evaluation and early clinical development of protein/RNA candidate viral vaccines by evaluating the immune response. The incumbent will develop and perform various assays to monitor the cellular and antibody immune responses elicited by vaccine candidates. This position will also be responsible for maintaining sample inventory for different studies and preparing samples for testing. Work is to be done in a compliant manner according to relevant SOP guidelines and cGLP and/or cGMP guidelines where appropriate. The incumbent will be part of a dynamic team and should possess a strong work ethic and collaborative spirit. ROLE RESPONSIBILITIES
- Perform ELISpot/FluoroSpot-based assays to measure cellular (B-cell and T-cell) immune response to vaccine candidates in preclinical and clinical studies.
- Ability to perform flow cytometry and Luminex-based assays to investigate the cellular phenotype and function. Maintain suspension and adherent cell lines by regular passaging and design and execute experiments to address research questions. Independently interpret and summarize experimental data.
- Analyze antibody responses to vaccine candidates using techniques that include (but are not limited to) cell culture, hemagglutination inhibition assays, neutralization assays, ELISAs.
- Analyze, document and report data in accordance with Pfizer/cGLP requirements. In collaboration with manager, interpret and summarize experimental data. Present experimental results at group meetings. Generate and characterize samples and reagents used to perform necessary assays and support maintenance of laboratory supplies.
- Maintain laboratory notebooks in compliance with the Pfizer Laboratory Notebook Policy.
- Perform other duties as assigned to support the group with different projects.
- Satisfactorily complete all safety training in conformance with Departmental requirements. Where applicable, performs job responsibilities in compliance with cGMP/GLP and all other regulatory agency requirements.
- B.S. in Biological Sciences with 3+ years OR Master's degree in Immunology, with laboratory research experience.
- Industry experience is a plus.
- Knowledge of methods in cellular immunology is highly preferred.
- Proficiency with personal computers including Word, Excel, GraphPad Prism, PowerPoint and relevant scientific software is desirable.
Other Job Details:
- Basic laboratory training in aseptic technique is essential.
- Ability to work with human/non-human primate (NHP) samples and infectious agents safely.
- The capacity to work effectively in a highly visible research program with time-constrained milestones.
Eligible for Relocation Package
Eligible for Employee Referral Bonus
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Research and Development