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Director, Computational Biology

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Closing date
Jun 28, 2022

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Discipline
Life Sciences, Biology, Computational Biology
Position Type
Full Time
Job Type
President/CEO/Director/VP
Organization Type
Pharma
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ROLE SUMMARY
  • Pfizer is making significant investment in the creation of novel, first-in-class therapeutics, by combining internal discovery and validation of drug targets with external partnerships to find the most innovative ideas, bring them to Pfizer R&D organization and move them to the clinic to deliver breakthroughs to patients.
  • This position is within Target Sciences (TS) team which works together with Pfizer's alternative drug discovery model Centers for Therapeutic Innovation (CTI) within Pfizer's broader Emerging Science & Innovation (ES&I) Unit. The primary responsibilities of this position are to lead computational biology efforts towards new and ongoing programs for ES&I portfolio through a combination of functional genomics, data mining and analysis of external and internal genetics and Omics data sets, and delivery of novel target hypotheses.
  • The Sr. Director will be accountable to and will work closely with lab-based biologists, computational biologists, and human geneticists to address key drug discovery questions on biological and disease mechanisms, biological rationale, target safety and patient stratification through the use of computational approaches to analyze and integrate in-house and public genetics, epigenetics, NGS and other Omics data types.
  • The Sr. Director will also work with other computational and statistics colleagues across the Integrative Biology groups within the Worldwide Research, Development, and Medical (WRDM) organization, Global Product Development (GPD), Real World Data (RWD), and Digital to leverage a broader suite of computational capabilities and analytical tools, lead the evaluation of cutting-edge tools to elucidate target and disease mechanisms, develop and test therapeutic hypotheses, identify disease biomarkers, and understand patient stratification.
  • The Sr. Director will work closely with Emerging Science Leads within ES&I and other stake holders providing guidance and evaluation on large investments (many WRDM or Pfizer wide) in AI and computational technologies.
  • The Sr. Director position requires deep expertise in computational biology, human genetics, drug development, with deep insights into at least one area of human biology as well as strong leadership and people management skills and the ability to lead, as a representative of Pfizer, key academic and industrial partnerships and consortia to support Target Sciences mission.


ROLE RESPONSIBILITIES
  • Lead a team of computational biologists within ESG group responsible for quantitative analysis, data integration, and methodology development for computational projects by interacting with internal experts in statistics, bioinformatics, computational biology, and research project leaders.
  • Lead internal and external collaborations that secure access to novel or proprietary data types and innovative computational methodologies to advance our ability to process and analyze novel biological data types and understand disease pathophysiology from large-scale molecular and phenotypic data.
  • Ensure excellence in execution of computational strategies, projects, and collaborations including study design, analysis, interpretation and timely delivery.
  • Help build strong AI capabilities within ES&I linked into WRDM Biomedicine Artificial Intelligence Center of Excellence, leverage AI for new target identification, biomarker discovery, advancement of RNA Therapeutics platform.
  • Lead internal efforts in evaluation and due diligence of new AI/ML opportunities and proactively establish a strong portfolio of collaborations focusing on ML method development and AI approaches that can be applied and implemented to enable and accelerate pipeline growth.
  • Lead internal and external efforts to provide actionable biological insights and build scientific rationale for specific drug targets and biological pathways across different disease areas including Rare Disease, Oncology, Inflammation & Immunology, and Internal Medicine through the development, implementation and application of tools and methods to analyze genetic, NGS (including but not limited to RNAseq, scRNAseq, etc), and other Omics data types.
  • Support RNA Therapeutics project pipeline including target prioritization, computational support of in vitro and in vivo studies to inform formulation selection, sequence optimization, dosing paradigms and provide insights into platform optimization. Design and implement computational biology pipelines and algorithms in collaboration with other computational biology scientists and bioinformatics engineers to support RNA therapeutic development and research activities.
  • Communicate and report study findings and analyses with leadership, administration, and collaborators. Manage, support, and promote relationships with the external community that can add value to target selection at Pfizer and enable collaborative use of Pfizer patient samples Work collaboratively with other human geneticists and computational biologists at Pfizer.

BASIC QUALIFICATIONS
  • Ph.D. in Biological Sciences, Bioinformatics, Molecular Biology, Biochemistry, Computer Science, Applied Mathematics, or related field required.
  • 10+ years of experience in healthcare or pharmaceutical industry leading computational teams and applying quantitative approaches to addressing biological questions. Demonstrated ability to influence and collaborate with peers, develop, and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
  • Track record working in matrixed cross-functional teams with demonstrated experience in design, execution, and interpretation of in vivo and/or in vitro biological experiments generating large scale molecular datasets, pathway analysis and NGSdata types.
  • Fluency in start-to-end analysis of multiple types of Omics data such as bulk RNAseq, scRNAseq, spatial transcriptomics, ChIP-seq, proteomics, metabolomics, or epigenetics with particular expertise in at least one of these. Sound statistical and quantitative skills with an understanding of the methods implemented by commonly used Omics data analysis packages.
  • Proficiency in artificial intelligence, machine/deep learning, and high-performance computing.
  • Extensive experience in bio-computational statistical programming languages (R) and working knowledge in one of the scripting/programing languages (Matlab/Python/Java) is essential.
  • Proven ability to build, lead, and manage teams and effectively interact with multidisciplinary scientists, researchers, and non-scientists.
  • Excellent communication, interpersonal, and presentation skills.
  • Track record of innovative and impactful research including peer-reviewed publications.
  • Strong desire and demonstrated ability to continually learn new skills.


PREFERRED QUALIFICATIONS
  • Demonstrated ability to establish and maintain networks and influence key internal and external decision makers, both in matrix environment and with direct reports.


Other Job Details

Eligible for Relocation Package

Eligible for Employee Referral Bonus

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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