This is a laboratory-based analytical Senior Scientist position in our Vaccines Research and Development - Analytical Development group. You will f ocus on developing robust analytical assays, and will design and execute method qualification and assay transfers in support of early vaccine development for a range of moieties with a focus on glycoconjugates, mRNAs, and proteins . Assays include use of standard analytical separations techniques (e.g., HPLC, SEC, CE, IEX, etc.) and spectroscopic techniques (e.g., DLS, UV-VIS, fluorescence, etc.).
In addition, you will provide analytical support for bioprocess and formulation development of vaccines by performing routine and non-routine sample testing.ROLE RESPONSIBILITIES
- Identify key quality attributes for new vaccine candidates such as glycoconjugates, proteins, or mRNAs, and contribute to the selection of analytical methodology and techniques to be used.
- Provide lab-based assay development support. Using knowledge of ICH guidelines for method qualification the individual would be expected to design, plan, and execute assay development, qualification and transfer studies with a high degree of independence.
- Establish and utilize new technologies, where required, to enhance our characterization toolbox and understanding about the drug products being developed.
- The individual will perform routine and non-routine sample analysis support for vaccine development.
- Plan and prioritize own assay development and analysis activities to ensure timelines are met.
- Author and review laboratory methods and reports.
- The individual is expected to contribute and participate in general laboratory maintenance activities (such as maintenance of equipment, managing laboratory waste.
- PhD in Chemistry, Biochemistry, or a related discipline with a minimum of 2 years of academic, pharmaceutical, or biotechnology experience OR an MS plus a minimum of 7 years of related work experience is required.
- A strong background in separation-based analytical techniques and method qualification following ICH guidelines is essential. Experience with applying these methodologies to mRNAs, proteins, or glycoconjugates is strongly preferred.
- Proficiency and ability to utilize analytical techniques such as HPLC separation methods, CE, DLS and UV-Vis to develop methods to characterize potential vaccine candidates. Experience with large biomolecules (e.g. mRNA and protein) is a plus.
- Strong verbal and written communication as well as excellent documentation skills are required.
OTHER JOB DETAILS
- Standard laboratory conditions - sitting, standing, primarily lab based
- Ability to perform mathematical calculations and ability to perform complex data analysis
Eligible for Relocation Package
Eligible for Employee Referral Bonus
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Research and Development