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Postdoc in the Research Group "Host Pathogen Interactions"

Langen (Hessen), Hessen (DE)
German E 14 TVöD Bund
Closing date
Jul 16, 2022
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A job opening is available in the Research Group "Host Pathogen Interactions" at the next possible starting date:


About the Paul-Ehrlich-Institut
We are a senior federal authority responsible for vaccines and biomedicines that performs scientific research in the field of life sciences. Our institute networks with national and international players which makes it a competent partner for the general public, science, medicine, politics, and economics.

About the group
The group focuses on the interaction between viruses and the innate immune system. We aim to identify new host factors involved in sensing and restricting viruses. We are employing state-of-the-art systems-based approaches (doi: 10.1016/j.chom.2015.11.002; doi: 10.1038/s41467-018-04671-1), CRISPR/Cas9 and iPSC technology to generate a deeper understanding on the cellular functions of the identified factors in infection (HIV-1, HCMV) and disease (interferonopathies, cancer: doi: 10.1007/s00109-021-02131-w). Additionally, the group incorporates a bioinformatics subgroup that focuses on next-generation sequencing/​metagenomics and machine learning approaches. The offered position is part of a third-party-funded project.

About the project – Key responsibilities
The Postdoc will work within a team of scientists working on various aspects understanding regulations and functions of SAMHD1. The position will focus on deciphering molecular interactions by proximity-labeling of mutated SAMHD1 leading to Aicardi–Goutières syndrome and of SAMHD1 in the context of infection. The goal is to understand the details of the mechanisms using genetically engineered CRISPR/Cas9 KI cells, Mass-spec, scRNAseq and methods for the study of innate immunity.

What we offer

  • Collaborative, interdisciplinary and dynamic research environment
  • Solid funding, allowing a high degree of flexibility
  • Cutting edge methodology and technology, high-throughput platforms
  • International network, collaboration and scientific exchange


  • PhD degree in life sciences or related
  • Excellent background in innate immunology or infectious disease research
  • Hands on experience elucidating innate immune responses
  • Methodological expertise in iPS cell culture, proximity-labeling (MS), CRISPR/Cas9, or virology is a plus
  • Team player and ability to supervise PhD and Master students
  • The successful candidate is expected to coordinate collaborative research activities and communicate in an interdisciplinary environment
  • Exceptional motivation and flexibility, a high degree of dedication and productivity
  • Excellent communication skills in English

Our Working Conditions

A multifaceted, and challenging position centrally located in the Rhine-Main area (Frankfurt) with good public transport connections. Being an employer in the German public service, we offer the usual social benefits.

The successful candidates will be employed on a fixed-term contract until December 31, 2024. Part-time working is possible in principle. The payband is E 14 TVöD Bund. The assignment to a payband is made based on the consideration of your individual professional experience. Disabled candidates will be given preference if their skills and qualifications are equivalent to those of non-disabled candidates. The Paul-Ehrlich-Institute encourages gender equality and life-work balance, especially in respect to the family. For this purpose, we have various employment models to offer including flexible working hours (part-time work, flexible working from home, teleworking, no core time), child care facilities and various opportunities for further professional training.

We look forward to receiving your online application (motivation letter, CV, reference letters) via our application management portal by July 17th, 2022 indicating JobID 881.

Apply now!

For questions related to the job application, please contact Kimberly Bremer (email:, phone: +49 6103 77-1105).

Please note that the German Federal Ministry of Health will in some cases (if required) be authorised to inspect your application documents under Section 6 (1), No. C, General Data Protection Regulation (GDPR) in connection with Section 2 (1) Gemeinsame Geschäftsordnung der Bundesministerien (joint rules of procedure of the federal ministries), and Article 65 of the German Constitution (Grundgesetz, Fundmental Law) to ensure a staff selection which fulfils its purpose and is in the interest of all parties involved. Your data will be erased immediately after the application procedure has been completed.

Das Paul-Ehrlich-Institut ist ein Bundesinstitut im Geschäftsbereich des Bundesministeriums für Gesundheit / The Paul-Ehrlich-Institut is an Agency of the German Federal Ministry of Health

Paul-Ehrlich-Straße 51-59
63225 Langen
Deutschland / Germany

Telefon / Phone +49 6103 77-0
Fax +49 6103 77-1234

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