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Expert Downstream Scientist - mRNA purification

Employer
GSK
Location
Rockville, Maryland
Salary
Competitive
Closing date
Jun 24, 2022

View more

Discipline
Physical Sciences, Chemistry
Job Type
Staff Scientist
Organization Type
All Industry, Pharma
Are you energized by a challenging role in biology, where scientific demand is driving team growth? If so, this Expert Scientist role would be a great opportunity to consider.

The Nucleic Acids Vaccines Center of Excellence global team (Technical Research & Development, GSK Vaccines) is seeking an enthusiastic, experienced and motivated Expert Scientist with a strong understanding and experience in downstream process development and nucleic acid research. Located in Rockville, MD, the position will contribute to the success of the GSK messenger RNA (mRNA) vaccine platform.

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following…
  • Drive development & optimization of a clinical & commercial manufacturing processes for the purification of mRNA and DNA.
  • Independently design and execute laboratory experiments.
  • Partner with diverse team members from various functions, multiple countries and members at various levels in organization.
  • Benchmark specific technologies in own functional area to bring technology to state of the art.
  • Solve complex problems through analytical thinking to identify and understand alternatives using knowledge gained through formal education, experience and sound judgment.
  • Prepare oral and written reports to communicate scientific findings and to support project documentation and CMC submissions.
  • Comply with data integrity requirements for laboratory work.


Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • Degree in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology, Bioengineering, or a related scientific field.
  • MS with 6+ years of experience or PhD with 2+ years of experience.
  • Experience in mRNA purification or experience of purification of biomolecules.
  • Experience with different purification techniques such as chromatography and tangential flow filtration (TFF) and associated instrumentation such as Akta chromatography systems and Unicorn software.
  • Experience with preparative HPLC.
  • Experience with bioanalytical assays associated with purification processes, such as SDS-PAGE, Western blotting, HPLC, etc.
  • Experience in research and development in a Biopharmaceutical industry or government laboratory setting.
  • Experience in experimental design and be able to independently execute laboratory experiments.


Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • Communicate effectively with regular verbal and formal updates to project teams and management.
  • Proficiency in English
  • Understanding of purification of biologics, specifically large size mRNA, including process scale-up.
  • Strong hands-on experience with a wide range of purification techniques for large nucleic acid molecules including affinity capture, ion exchange and hydrophobic interactions.
  • Experience and understanding of nucleic acid analytical technologies.
  • Understanding of Quality by Design and the development of a process control strategy.
  • Design and execute DOE studies & high-throughput screen for purification process improvements and advancements including parameter optimization, scale-up, process window determination and process capability evaluation.
  • Knowledge of technology transfer and GMP manufacturing.
  • Be able to rapidly acquire project understanding and apply professional knowledge to project improvement.
  • Demonstrated ability to efficiently work in a fast paced and fluid environment, changes in priority and timeline restrictions


Why GSK?

At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands. ​



With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive. ​



Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together. ​

#VaccinesRD

*LI-GSK

*This is a job description to aide in the job posting, but does not include all job evaluation details.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.

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