Analytica Development Scientist

Employer
Spark Therapeutics
Location
Philadelphia, Pennsylvania. Hybrid and remote options available for select opportunities.
Salary
Salary not provided
Closing date
Jul 15, 2022

View more

Discipline
Health Sciences, Drug Development
Job Type
Staff Scientist
Organization Type
Pharma

Job Details

The Analytical Development Scientist position plays a key role in Assay/Methodology development team. He/she will function as an expert to design and execute experiments to develop new analytical methods.

The incumbent will provide scientific expertise to multiple assay development projects, optimize existing assays based on in-depth knowledge of laboratory techniques. Provide scientific inputs on principle of new assay development process, technical transfer, development of SOPs and assay validation.

Perform analytical experiments to support upstream and downstream process development as needed. Participate in process characterization/validation work. Collaborate with analytical Science and QC teams to develop SOPs and transfer the developed assays to the corresponding teams.

The major responsibilities are as follows, but not limited to:

  • Independently designs and develop Cell-based and/or immunoassays to characterize potency of rAAV vector product and their associated variants and major impurities.
  • Fundamental and proficient experience with cell-based bioassays and immunoassays
  • Demonstrated proficiency with biological techniques (Viral infectivity and potency assays, ELISA, cell culture, RT-PCR, immunostaining...etc.) for biotherapeutic characterization.
  • Provide analytical expertise to troubleshoot and resolve technical issues.
  • Conduct analytical experiments to support process and technology development, and to deliver a reliable high-quality experimental data and prepare experimental reports in a timely manner.
  • Write, review, edit, and approval internal technical reports, quality documents and external presentations.
  • Demonstrated ability to support assay transfer to external vendors.
  • Expert technical lab skills.
  • Expert skills in synthesizing research findings and effectively communicating findings and recommendations to senior management and project teams independently.
  • Acts independently to determine methods and procedures on new assignments.

Education and Experience Requirements

  • Typically, Ph.D. in Biological sciences field or BS/MS in Biological Sciences field with 5 years of related experience in biotechnology or pharmaceutical industry settings.
  • Experience with viral vector production and characterization is preferred.

#LI-2326

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.


Nearest Major Market: Philadelphia



Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

Company

At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
Website
Telephone
215-989-1149
Location
3737 Market Street
Suite 1300
Philadelphia
PA
19104
United States

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert