This job has expired

Research Associate - Neutralizing Assay Team

Employer
Spark Therapeutics
Location
Philadelphia, Pennsylvania. Hybrid and remote options available for select opportunities.
Salary
Salary not provided
Closing date
Jun 30, 2022

View more

Discipline
Health Sciences, Drug Development
Job Type
Research Scientist
Organization Type
Pharma
You need to sign in or create an account to save a job.

Job Details

Primary Duties

The Research Associate will report to the Neutralization Assay Team Lead. He/She will conduct routine sample analysis using well-established cell-based neutralizing antibody (NAb) assays to support patient screening and selection across programs in a GLP/GCP compliant manner and maintain accurate, timely and detailed record of work. The candidate will also provide preclinical support for GLP studies. The incumbent will also evaluate post-infusion NAb responses in patients and contribute to assay modifications and assay qualifications related to continued improvement of existing assays and standard operating procedures. The candidate will keep track of long-term assay performance and data trends and proactively trouble-shoot assay related issues. He/She will work with team members and ensure adequate materials and reagent supply and qualify new reagent lots as needed. He/She will participate in exploratory evaluations of new NAb assay technologies and contribute NAb assay data to help understand correlation with total antibodies. He/She will interface with clinical operations, sample management and LIMS group for sample shipment schedules, sample handling and chain-of-custody related workflow and author SOPS and conduct periodic reviews of documents.

Responsibilities

Experimental design, lab work and data analysis

Regulated and non-regulated bioanalysis related documentation

Miscellaneous bioanalytical department and company related tasks and trainings

Education and Experience Requirements

BA/BS in biological sciences required. Master’s degree preferred. Generally, has at least 3-5 years of relevant experience

Key Skills, Abilities, and Competencies

  • Cell-based assay experience is a must.
  • Ability to perform tasks independently. Ability to learn new techniques and perform multiple tasks.
  • Be self-motivated, adaptable and have a positive attitude especially when dealing with challenges.
  • Excellent organizational, communication and collaboration skills
  • Work is performed without appreciable direction.
  • Exercises considerable latitude in determining objectives and approaches to assignment
  • Keep accurate records, comply with Good Documentation Practice, follow instructions, and comply with company policies. Familiarity with Electronic Lab Notebook (ELN) and Lab Information Management Systems (LIMS).
Other Job Requirements

  • Attendance at one relevant conference per year and participation in internal and cross-functional team meetings are expected.
  • On site lab benchwork is expected.
  • Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.


Nearest Major Market: Philadelphia



Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

Company

At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
Website
Telephone
215-989-1149
Location
3737 Market Street
Suite 1300
Philadelphia
PA
19104
United States
You need to sign in or create an account to save a job.

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert