The Tran lab in the Department of Molecular and Human Genetics is seeking a talented and motivated Postdoctoral Associate to lead projects that will examine the molecular mechanisms of neurodegeneration and axon regeneration in the central nervous system (CNS).
About our research: CNS neurons have a limited ability to recover from damage and for many neurodegenerative conditions there are limited treatment options. Our lab uses a variety of mouse genetic and high throughput single-cell multi-omic approaches to dissect the molecular pathways that mediate neuronal survival and growth at tissue scale with cellular resolution. We utilize the retina as an approachable part of the CNS to study these processes. Our goal is to identify and study factors that can promote neuroprotection and simulate regeneration in the adult CNS.
To learn more about our research please visit the following webpage: https://nmtranlab.com/
The successful candidate will have the opportunity to pursue a research direction in one of several research areas:
• Single-cell transcriptomic and epigenetic approaches to study neurodegeneration - We have established a comprehensive molecular atlas of retinal cell types by profiling >250,000 cells by scRNA-seq. We are now exploring gene regulatory networks in degenerative conditions (optic nerve injury and glaucoma) and how these are modulated by regenerative treatments.
• Mechanistic characterization of genetic targets that promote neuroprotection and axon regeneration- Our scRNA-seq expression screens have revealed a number of novel targets for regenerative intervention. We are investigating the molecular function of these and other treatments to identify the core molecular pathways regulating these processes.
• Gene therapy for optic neuropathies- Building on our experience in neurodegeneration, we are developing translational approaches for the treatment of optic neuropathies with a primary focus on glaucoma.
BCM is centrally situated in Houston in the Texas Medical Center, the largest biomedical research center in the world, offering exceptional collaborative opportunities and resources. The Molecular and Human Genetics department consistently ranks nationally among the top genetics departments for NIH funding. The Postdoctoral Associate will have access to BCM's world-class advanced technology cores, animal facilities, and high-performance computational resources to conduct their experiments. Houston is among the most diverse cities in the country, with many cultural amenities, world-class museums, urban parks, and a relatively low cost of living for a large metropolitan area.
The Postdoctoral Associate will design and conduct experiments and analyze results under the guidance of the PI. Specific experimental duties will depend on the research topic of choice but will be expected to cover a broad range of molecular and genetic approaches. Job Duties
- Maintain an organized daily electronic laboratory notebook.
- Regularly meet with Dr. Tran to discuss their work.
- Present results in professional forums (seminars, meetings, and conferences) .
- Publish findings in peer-reviewed journals.
- Perform assigned general laboratory chores.
- MD or Ph.D. in Basic Science, Health Science, or a related field.
- No experience required.
- Strong academic training in genetics and neurobiology
- Demonstrated interest in vision science, neurodegeneration, and/or axon regeneration
- Experience in animal surgery, immunohistochemistry, and molecular biology
- Experience in bioinformatics and single-cell genomics a plus
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.