A postdoctoral associate position is available in Dr. Xia Gao's laboratory in the Department of Pediatrics at Baylor College of Medicine. We are interested in the interactions of nutrition, metabolism, and the development and treatment of metabolic diseases such as obesity and cancer. The goal is to identify nutritional interventions and metabolic pathways for prevention and treatment of metabolic diseases. We employ untargeted and targeted metabolomic analysis and isotope tracing studies using newly vested in-house Thermo Exploris 480 LC/MS instrument. Along with this powerful analytical tool, we use various in vivo mouse models and in vitro models to define the role of nutritional input and the underlying mechanisms in disease development and control. For instance, we have recently (Nature, 2019) employed metabolomics approaches to show that dietary methionine restriction is an effective and feasible dietary intervention in healthy humans and mice to alter circulating metabolism without overt side effect. Dietary methionine restriction has shown promising in various mouse cancer models alone or in combination with chemotherapy or radiotherapy. Job Duties
- Defines the mechanisms underlying methionine restriction mediated tumor inhibition.
- Determines the therapeutic potential of dietary methionine restriction in various cancer types and stages.
- Investigates amino acid metabolism in cancer and obesity.
- MD or Ph.D. in Basic Science, Health Science, or a related field.
- No experience required.
- Prior experience or expertise in:
- and others are encouraged to apply.
Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
PD; CA; SN