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Staff Scientist - CAR T Cell Therapy

City of Hope
Duarte, California
Closing date
Jul 20, 2022

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Life Sciences, Cell Biology, Physical Sciences, Chemistry
Position Type
Full Time
Organization Type
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Job Details

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

The T cell Therapeutics Laboratories is comprised of five individual laboratories focused on developing novel CAR T cell Immunotherapies. The molecular team has historically designed and produced most of the chimeric antigen receptors used in the studies across all laboratories. This position on the Molecular team is immediately available for an independent, organized, self-motivated individual with extensive molecular biology experience that would work with all 5 PIs to design and develop novel receptors and to manage the molecular workstations.

Key Responsibilities include:
  • Primary responsibilities for the T Cell Therapeutics research laboratories (TCTRL) program/department would include construct design; management and organization of the molecular workstations, database, and software related to construct design; training of new staff for all projects for labs within the TCTRL program/department
  • Molecular techniques to be performed, including but not limited to molecular design, generation of molecular constructs, plasmid and genomic DNA purification, PCR, quantitative PCR, Western blot, southern blot, transient and stable transfection, passage and maintenance of tissue culture cell lines
  • Development and standardization of molecular assays for quality control (QC) and correlative assays investigating patient products and samples.

Basic education, experience and skills required for consideration:
  • The Staff Scientist must possess, at a minimum, the U.S. equivalent Bachelor's or Master's degree in an appropriate discipline, and will often have a Ph.D. or other doctoral level degree.
  • A minimum 5 years of laboratory experience specifically in Molecular Biological Sciences or related field.
  • Must have demonstrable computer skills in Microsoft Word, Excel, and proficiency in utilizing CLC Bio and Snapgene (or similar programs) is highly preferred, as well as skills in data management and analyses.

Additional Information:
  • For an overview of the lab's research interests, please visithere.
  • As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

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