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Associate Scientist, Upstream Process Development

Employer
Pfizer
Location
Andover, Massachusetts
Salary
Competitive
Closing date
May 24, 2022

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Discipline
Physical Sciences, Chemistry, Other, Manufacturing/QA/QC
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
Pharma
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

In this role, you will join a team of scientists and engineers focused on developing and optimizing mammalian cell culture processes and in vitro transcription (IVT) processes for production of recombinant proteins and biologics for early and late-phase human clinical trials. Your work will be involved in cutting edge technology development projects that seek to probe/understand cellular physiology in the context of biologics production and discover broadly applicable methods to intensify mammalian cell culture processes and IVT processes .

As an Associate S cientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. Your strong foundation in general scientific practice, its principles and concepts will help in meeting critical deadlines. You will be relied on as a technical contributor to assess the assigned tasks and make decisions that involve direct application of your knowledge.

It is your hard work and dedication that will make Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It
  • Plan and execute experiments in shake flasks, bench-top bioreactors, and other appropriate scale-down equipment for development of mammalian cell culture processes and/or IVT processes for producing therapeutic biological molecules of interest.
  • Work on cutting edge technology development projects that seek to discover broadly applicable methods to intensify mammalian cell culture and/or IVT processes.
  • Effectively document all lab activities in notebooks and author technical reports as required and appropriate, in a timely fashion.
  • Communicate results and findings to stake-holders on a regular basis; present data/strategy to colleagues and management in internal and external venues (technical meetings, project team meetings, and conferences, etc.) as appropriate.
  • Assist in the tech transfer of manufacturing processes to pilot, clinical, and commercial facilities. Provide support and troubleshoot during manufacturing campaign as needed.
  • Work collaboratively with colleagues both within the group and cross-functionally; contribute to maintaining and improving upon our safe, effective and efficient lab operations.


Basic Qualifications
  • BS/BA in Chemical Engineering, Biochemical Engineering, Biotechnology, Microbiology, Cell Biology, Biochemistry or equivalent with 0-2 year's industrial experience.
  • Aseptic laboratory technique, basic understanding of bioreactor operation. Basic knowledge of mammalian cell culture, metabolism and DNA transcription.
  • Ability to grasp scientific concepts, interpret data, and formulate new hypothesis.
  • Team oriented, with excellent oral and written communication skills. Well organized and great attention to detail.


Preferred Qualifications
  • Experience in bench scale (1L) bioreactor operation.
  • Practical knowledge of mammalian expression systems or IVT processes.
  • Experience in developing commercially relevant cell culture or IVT processes to produce pharmacologically active molecules.
  • Experience in supporting the scale-up and technology transfer to pilot/commercial scales.
  • Knowledge of GLP/GMP practices.
  • Experience with technical report writing.
  • Experience with or knowledge of miniature bioreactors (ambr15 and ambr250) operation.


Work Location Assignment: Flexible

PHYSICAL/MENTAL REQUIREMENTS
  • Position requires occasional light lifting and periods of standing, sitting or walking.


NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
  • Occasional weekend work required.
  • Occasional travel domestically to support technology development and/or clinical manufacturing activities as well as technology transfer to commercial manufacturing.
Relocation support available

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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