What You Will Achieve
Pfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a Senior Scientist focused on translating basic discoveries in the field of tumor biology into novel therapeutics.
The candidate will lead translational development efforts supporting drug programs currently in clinical development and/or advanced pre-clinical drug discovery stages. Our ideal candidate will have strong translational research experience with hands-on expertise in conducting drug mechanism of action studies, elucidation of drug resistance mechanisms and development of rational drug combination strategies. The candidate will lead biological translational studies utilizing genetic and pharmacological approaches to understand MOA and generate patient stratification strategies for novel cancer therapeutics. As a member of the group, the candidate will work together with a team of motivated and scientifically rigorous scientists to perform laboratory-based research in a collaborative team environment, interpret and present findings at team/project meetings and function as an integral member of the team to advance drug programs.How You Will Achieve It
- Perform routine cell culture and molecular biology experiments to support discovering novel targets/therapeutics, target evaluation and mechanism of action studies for cancer.
- Independently able to develop and apply complex in vitro assays for conducting synthetic-lethal, drug combination screens to identify rational combinations and patient selection biomarkers.
- Collaborate with in vivo pharmacology group for efficacy testing, PK/PD and experimental design of preclinical PoC experiments and develop cell assays to measure pharmacodynamic changes, kinetics of drug response and evaluation of predictive biomarkers.
- Critically analyze/interpret complex data and able to present research results and methodologies at weekly meetings with immediate supervisor and/or project leader, and other research forums.
- Document experiments and data analysis in E-Workbook.
- Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development.
- Regularly contribute and influence at the project team level.
- Collaborate with Pfizer teams and development group to pursue the most promising drug incumbents through clinical trials.
- Effectively collaborate with other members of the Oncology Research & Discovery and supporting partner lines.
- Assist Lead Biomarker Scientist to develop, optimize, validate, and perform FACS-based and other biomarker assays to support studies in Clinical Research Unit (CRU) and external protocols.
- Develop tool assets for advancing systems biology group projects including cell models of disease, chemical probe validation, and molecular library construction.
- Supervise colleagues in design and execution of experiments.
- Identify, trouble-shoot, and optimize relevant assay systems, technologies, and readouts.
- Conduct research that leads to publication in peer-reviewed journals and presentation of data at internal and external meetings.
- BS or MS in Molecular or Cellular Biology, Genetics, Pharmacology (or a comparable biological science) with a minimum of 9+ years of relevant experience in an academic or pharmaceutical/biotech environment.
- Significant experience designing, conducting and analyzing cancer drug combination studies.
- Demonstrate proficiency in the use of software tools to support data capture/analysis tools, such as Excel, GraphPad, Spotfire, and PowerPoint for data analysis/presentations.
- Experience in use of CRISPR-based techniques for gene knockout, shRNA knockdown and as well as working knowledge of pooled CRISPR -based screening approaches.
- Utilize 2D and 3D (spheroid models, organoid, co-culture systems, etc.) assays to measure cell proliferation, migration, and invasion.
- Perform cell-based assays across various technology platforms to assess target modulation and measure downstream signaling pathways- qPCR, ChIP-seq, FACS, immunofluorescence, western blotting, ELISA, high content screening, etc.
- Demonstrated ability to effectively interact and communicate in multidisciplinary project teams, including solid verbal and written communication and presentation skills.
- Strong track record in cancer drug discovery/translational research and the development of small-molecule inhibitors.
- Extensive experience in cancer research, tumor microenvironment biology, immunology, or related fields, and a desire to continue in a laboratory-focused role
- Specific expertise in the study of cell cycle related Cyclin Dependent Kinases including direct assessments of cellular activity, localization and interaction with their molecular networks
Other Job Details
- Perform work in a laboratory setting
- Extended periods of sitting and standing
- Last Date to Apply: May 23rd, 2022
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Research and Development