Site Name: USA - Pennsylvania - Upper Providence Posted Date: Mar 23 2022 Are you energized by the challenge of applying your skills in molecular and cellular biology to the identification and validation of new targets for drug discovery? If so, this Biology Senior Scientist role could be an exciting opportunity to consider. As a senior scientist within the Novel Human Genetics Research Unit you will be responsible for conducting experiments to drive new target discovery efforts forward, particularly within the renal, hepatic, metabolic, and cardiovascular therapeutic areas. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include: Developing and executing biochemical and cell biology experiments, such as gene expression analysis, ELISA, immunoblotting, and high content cellular imaging, to identify and validate novel drug targets across a range of disease indications. Interpreting data from a wide variety of sources―including the scientific literature and human genetic association studies―to provide support for new discovery projects Communicating your data to highly motivated and enthusiastic matrix teams Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: BS/MS degree with 2+ years of experience in biology, biochemistry, pharmacology, molecular/cellular biology, immunology, or a related discipline. Experience in basic molecular biology methods, including PCR and nucleic acid isolation, and routine mammalian cell isolation and culture methods. Experience with the design and execution of biochemical and cell-based assays, including the application of enzyme activity and protein binding techniques, and the investigation of cellular signaling pathways using ELISA, immunoblotting, and gene expression analysis Preferred Qualifications: If you have the following characteristics, it would be a plus: Experience with gene expression and genomic manipulation techniques, such as siRNA/shRNA, CRISPR, and lentiviruses Experience with the isolation and handling of induced pluripotent stem cells (iPSCs) Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. 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