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Investigator - LC-MS Protein Characterization

Collegeville, PA
Closing date
May 22, 2022

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Other, Other
Job Type
Group Leader/Principal Investigator
Organization Type
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Site Name: USA - Pennsylvania - Upper Providence Posted Date: Dec 23 2021 GlaxoSmithKline has an immediate opening for an Investigator position - LC-MS and protein characterization in Collegeville, PA. The mass spectrometry group is well equipped with modern instrumentation including Synapt G2S with both H/DX and IM, Xevo G2-XS, Orbitrap Fusion Tribrid, Orbitrap XL, Exploris 480, Eclipse Tribrid, Q Exactive Plus, 2D-NanoUPLC, Nano-UPLC, UPLC and many other supporting instrumentation and associated data analysis software. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following… Developing mass spec-based analytical strategies & methods (e.g. LC-MS and LC-MS/MS) Perform analysis for the characterization and comparability evaluation of therapeutic proteins. Apply advanced methods and techniques, including immunoprecipitations and/or other small-scale purifications Develop other analytical and/or biochemical methods to deepen the understanding of protein structure -function relationships Represent the group in project matrix teams to provide Subject Expert Matter (SME) inputs in supporting clinical studies through commercial biopharmaceutical process development and manufacturing. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: MS with 8+ years of experience in biotech or pharmaceutical industry or a Ph.D with 3+ years of experience Experience with in protein characterization mass spectrometry, with hands-on experience on various high-resolution accurate mass LC-MS instruments operation, nano-LC fluidics and LC-MS/MS methods, data processing software and workflows. Experience in mass spectrometry instrumentation, maintenance, and troubleshooting Experience in participating and supporting biopharmaceutical analytical development at different stages Preferred Qualifications: If you have the following characteristics, it would be a plus: Experience in analysis of protein therapeutics using platform assays like intact/reduced, peptide mapping and advanced/novel technologies Scientific working knowledge in the structure and function of protein therapeutics Knowledge and hands-on experience in various separation techniques such as immunoprecipitation or other in vitro purification, CE, SEC, IEX and HPLC/UPLC Experience supporting FTIH through commercial stage of biopharmaceutical development The candidate is expected to be highly motivated with excellent communication skills, both written and verbal. Candidate should be an instinctive team player with excellent people skills. Experience in developing cutting-edge LC-MS/MS workflows for therapeutic proteins including mAbs, ADCs, and bispecifics is highly desirable. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. #GSKBiopharm_Development *LI-GSK #GSKBiopharm_Development If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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