Site Name: USA - Pennsylvania - Upper Providence Posted Date: May 18 2022 Are you passionate about the application of gene editing in stem cell models to uncover novel targets to deliver the next generation of innovative medicines to patients? If so, this Scientific Principal Investigator opportunity might be for you. Our Functional Genomics department at GSK comprises of several disciplines that provide the deep scientific knowledge and technical capabilities required to discover and validate potential novel therapeutic targets through the application of extensive genetic analyses, high throughput genome editing and endophenotyping in well-characterised human cellular and in vivo models. We aim to redefine how the industry approaches drug discovery to deliver transformative medicines for our patients by working together with our world-leading partnerships with the UK BioBank, 23andMe, Altius Institute, Open Targets, and the Laboratory of Genomics Research (LGR) with CRISPR pioneer Jennifer Doudna. Together, we can draw on genotypic and phenotypic databases to interrogate the genome. An exciting opportunity is available for a highly motivated and experienced stem cell scientist to lead our stem cell group as a Principal Investigator within the Translational Cell Sciences group at our US research hub. The successful candidate will be responsible for the conceptual design and execution, both directly and by leadership of a small team of scientists, of large scale functional genomics studies in stem cell model systems for target discovery, validation and pathway studies of critical importance to the GSK R&D pipeline, with a focus on genetically driven diseases in immunology and neurodegeneration. Working in this multi-faceted, dynamic, and cutting-edge scientific environment, this Principal Investigator role will give you the opportunity to lead key activities to progress YOUR career and include some of the following… Design and implement large-scale functional genomic and bespoke disease modelling studies, with a particular focus on immunology & neurodegeneration research priorities, employing physiological- and/or disease-relevant cellular models and assays Lead a team of stem cell biologists to deliver on multiple projects in priority disease areas for GSK, build productive collaborations with GSK scientific partners and external partners, locally and globally Work in a matrix team environment to drive timely delivery of project and department objectives to the highest scientific standard. Evaluate and implement innovative technologies (incl automation) as appropriate to ensure GSK is highly competitive in functional genomics and facilitate their broad implementation across ongoing target discovery and validation efforts Communicate experimental findings effectively, in written and verbal formats to multiple internal and external stakeholders Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practices. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: PhD or equivalent in Cell or Molecular Biology (or related subjects) with extensive stem cell research experience in industry or academia in the area of target identification and validation. Preferred Qualifications: If you have the following characteristics, it would be a plus: Extensive scientific understanding in immunology or neurodegeneration disease biology. Familiarity with genetic, proteomic, imaging, and/or other ‘omics technologies. Ability to formulate and communicate a coherent vision/research plan. Evidence of leading new technology initiatives, working with commercial partners to evaluate and implement new technologies relevant to target identification and or validation. Extensive practical experience in the experimental design, execution and data analysis of experiments to identify novel biology or new targets using genomics and other approaches. Experience of direct management of scientists with excellent team working behaviours, matrix working, interpersonal and communication skills. Evidence of conducting and interpreting perturbation studies using tool compounds, gene knockdown or gene editing approaches in stem cell models, preferably CRISPRn/i/a. Experience conducting functional in vitro assays at scale, such as ELISA, flow cytometry, and western blotting. Strong publication record in functional genomics or stem cell related fields. Evidence of managing complex projects across lines and functions. Evidence of working in large academic collaborations with the ability to build relationships. Demonstrated ability to analyse complex integrated datasets across multiple genomics platforms. Strong influencing and analytical skills coupled with the ability to problem solve. Highly committed, enthusiastic, self-motivated and demonstrate a passion for learning. Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. 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