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Senior Scientist - Genome Biology, GS

Collegeville, PA
Closing date
May 20, 2022

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Life Sciences, Biology, Physical Sciences, Chemistry
Job Type
Senior Scientist
Organization Type
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Site Name: USA - Pennsylvania - Upper Providence Posted Date: May 6 2022 Are you inquisitive? Creative? Bold? GlaxoSmithKline is a science-led global pharmaceutical company that researches and develops a broad range of innovative products to improve the quality of human life by enabling people to do more, feel better and live longer. We need individuals like you, with an established track record in cellular and molecular biology to join a team of diverse, multi-disciplinary scientists, who will develop and execute state-of-the-art CRISPR arrayed screening. The successful candidate will join the Genome Biology group within Genomic Sciences (GS). In partnership with Research Units and the Artificial Intelligence and Machine Learning (AIML) group, we strive to expand our understanding of the genetics of disease and associated cellular endophenotypes, reveal mechanisms of drug action and resistance, and fuel the discovery of new targets and combination therapies. Key Responsibilities: Develop, optimize and deploy protocols for mammalian cell-based assays Maintain and characterize human cell line cultures. Contribute to capability development and arrayed screening programs. Develop and effectively apply a broad spectrum of practical laboratory skills. Present clear and concise written and oral communications to colleagues and supervisors, participate in technical meetings, and provide recommendations based on technical results. Ensure compliance with all GSK R&D data integrity practices, ethics codes, work practice training and standards. Basic Qualifications: Bachelor's or Master's degree in biology or a life science field with 2+ years of research experience. Proficient in the culture and maintenance of cell lines or primary cells. Experience in molecular techniques such as DNA isolation, PCR, Sanger sequencing or primer design. Experience in developing assays to characterize human cells (e.g. CellTiter-Glo, high throughput flow cytometry or image-based high content screening). Experience with gene editing or modulation techniques (siRNA, CRISPR, TALE, RNAi). Preferred Qualifications: Scientific expertise in genetics, immunology, or oncology Experience working in an industry or pharma setting. Familiarity with automation techniques such as liquid handlers (e.g. Hamilton Bravo, GNF Washer/Dispenser) and multidrop dispensers. Expertise in development and execution of high-throughput arrayed phenotypic screening. Experience with high throughput electroporation platforms or high throughput genomic profiling. Familiarity with lentiviral transduction in cell lines and primary cells. Strong organizational and communication skills (both written and oral), with the ability to liaise with colleagues at all levels. Ability to think creatively, demonstrate flexibility, and engage with team members while troubleshooting and optimizing assays with a willingness to learn in a matrix team environment. Track record of attention to detail and the ability to maintain detailed laboratory notebook records. Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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