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Investigator, Clinical Histotechnology

Collegeville, PA
Closing date
May 22, 2022

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Other, Other
Job Type
Group Leader/Principal Investigator
Organization Type
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Site Name: USA - Pennsylvania - Upper Providence Posted Date: Apr 29 2022 We are looking for a talented investigator to join our growing Clinical Histotechnology group at Upper Providence. This laboratory-based position will provide biomarker assay support to early-stage clinical trials across GSK's wide portfolio of assets. The individual in this role will develop and evaluate clinical biomarker assays using immunohistochemistry (IHC), immunofluorescence (IF) and in situ hybridization (ISH) techniques, as well as utilize high-plex imaging platforms including Digital Spatial Profiling (DSP) and Imaging Mass Cytometry (IMC). They will also use Image Analysis software (HALO) to develop automated and machine-learning (AI) algorithms to measure tissue biomarker expression to provide quantitative data to clinical teams. This exciting role will provide you with the opportunity to lead key biomarker projects as well as be involved in many other activities to progress your career. Responsibilities include: Use a broad knowledge of histotechnology to guide clinical teams towards the best-suited biomarkers and assays across GSK's wide portfolio of projects. Develop single- and multi-plex IHC/IF/ISH and/or high-plex assays using automated platforms including Ventana Discovery Ultra, Leica Bond RX, Nanostring DSP and Hyperion IMC. Develop and evaluate automated and/or machine learning (AI) algorithms using Image Analysis software (HALO) software to generate quantitative analytical data. Work closely with GSK Pathologists to critically evaluate biomarker assays and image analysis algorithms to ensure high quality results. Compile reports and write standard operating procedures, analytical methods, and protocols. Provide necessary training and help troubleshoot issues within the team. Develop trusted connections in the histotechnology and wider scientific community (internally and externally to GSK) through meetings, publications and presentations at conferences hosted by professional societies. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Bachelor's/Master's degree in biological sciences or a relevant scientific field (immunology, molecular biology, cancer biology, neurobiology). Experience in inflammatory diseases and/or immuno-oncology. Experience in microtomy. 2 years' IHC experience developing single- and multi-plex IHC/IF/ISH biomarker assays or using high-plex IMC or DSP platforms. Preferred Qualifications: If you have the following characteristics, it would be a plus: PhD in biological science or a relevant scientific field (immunology, molecular biology, cancer biology neurobiology). 1-2 years' experience using Image Analysis software to develop automated and machine-learning (AI) algorithms to quantify IHC/IF/ISH assays. Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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