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Structural Biology Investigator

Collegeville, PA
Closing date
May 22, 2022

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Site Name: USA - Pennsylvania - Upper Providence Posted Date: May 6 2022 Are you energized by a highly collaborative scientific role in drug discovery that allows you to impact scientific strategy and accelerate R&D delivery? If so, this role could be an ideal opportunity to explore. An exciting opportunity is available within Structural and Biophysical Sciences, which is part of Medicine Design at the GSK US R&D hub in Upper Providence, Pennsylvania. GSK is seeking a highly motivated and creative structural biologist to impact drug discovery programs through delivery of high-resolution structural data and integration of structural data with results from partnering groups. Our department combines structural biology with biophysical data to understand and optimize interactions between drug targets and small molecule hits, leads, and candidates to support discovery across all therapeutic areas under investigation at GSK. Our group interacts broadly with project teams consisting of biologists, medicinal chemists, biochemists, and computational chemists to discover and optimize novel therapeutics. This position requires excellent communication, organizational, and interpersonal skills and the ability to influence diverse drug discovery teams using robust science. This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following: Solve x-ray crystal structures from in house and synchrotron diffraction data sources using molecular replacement and experimental phasing methods for protein:ligand, protein:protein, and protein:nucleic acid complexes. Initiate structural biology on new programs by working with computational and biochemical scientists to design protein constructs and build comprehensive plans to yield structural data relevant to the discovery campaigns. Carefully design and carry out experiments to integrate structural and biophysical mechanisms to generate actionable information for the advancement of drug discovery campaigns. Characterize purified protein drug targets and protein:ligand interactions using biophysical methods. Prepare research reports, give internal and external presentations, champion and contribute to publications. Maintain current knowledge of structural biology literature to keep abreast of new technologies well suited for drug discovery and the GSK R&D strategy. Implement creative new methods, protocols, and technologies to advance the efficiency, speed, and success-rate of structural biology techniques for complex systems. Interact with business partners including therapeutic-area focused research units, biophysicists, medicinal chemists, and counterpart technology groups. Liaise and consult as a representative to program teams. Why You? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: A Ph.D. in Structural Biology, Biophysics, Biochemistry, Chemistry, Chemical Biology or related field, plus 2 years of post-doc experience or a BS/MS with 5 + years relevant industry experience in a related discipline Preferred Qualifications: If you have the following characteristics, it would be a plus: Deep understanding and demonstrated expertise in x-ray crystallography and protein crystallization with a strong knowledge of biophysics and biochemistry. Computational skills Strong track record of publications in peer reviewed journal Linux system management, data pipelines and automation of data analysis, scripting/coding, x-ray facility management, and high performance computing. Cryo-EM grid preparation, data collection, or data processing/analysis for protein structure determination. Biophysical methods including surface plasmon resonance (SPR), microscale thermophoresis (MST), or nuclear magnetic resonance (NMR). Experience with quantitative protein biophysics and molecular interaction analysis. Demonstrated strengths in high performance behaviors, such as building relationships, flexible thinking, and enabling/driving change. Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK #LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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