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HTPD formulation associate

Employer
Spark Therapeutics
Location
Philadelphia, Pennsylvania. Hybrid and remote options available for select opportunities.
Salary
Salary not provided
Closing date
Jun 17, 2022

View more

Discipline
Physical Sciences, Chemistry
Organization Type
Pharma
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Job Details

The High-Throughput Process Development team is seeking a highly motivated associate to support high-throughput formulation development. The role will use automation to study and optimize storage of adeno-associated viral vectors in Spark’s industry-leading gene therapy programs.

The candidate will work with senior automation and formulation scientists to utilize cutting-edge automation systems to conduct stability studies, and a variety of analytical HPLC and particulate detection systems to assess changes in quality.

The candidate must have laboratory experience in bioengineering or biochemistry, with experience in either (a) formulation development of biologics, (b) analytical HPLC (ion exchange, size-exclusion), or (c) analytical subvisible particulate studies.

Familiarity with automation systems (Tecan, Hamilton, Unchained Labs), a programming language (Python, Matlab, Visual Basic, R), or multivariate statistics (DoE, JMP, Design Expert) are preferred but not required.

The major responsibilities include, but are not limited to:

• Use automation systems to execute high-throughput stability studies

• Analytical testing of samples from studies using HPLC, particulate detection, or similar.

• Work with automation scientists to customize automation methods for key studies

• Work with formulation scientists to design and execute key studies

• Analytical testing to support key formulation development activities

• Organize and analyze data in clear, concise, and timely manner

30%

Use automation systems to execute high-throughput formulation development studies

30%

Analytical testing of samples from studies using HPLC, particulate detection, or similar.

20%

Work with automation scientists to customize automation methods for formulation development studies

10%

Prepare process development reports and technical documents

10%

Prepare presentations in various team and project meetings.

Education/Basic Requirements

Required

• BS/MS degree in biochemistry, chemistry, chemical engineering, bioengineering, or related area with laboratory experience (3 year BS, 1 year MS).

• Experience with one of analytical chromatography (ion exchange, size exclusion), light scattering (DLS, SLS), or subvisible particle characterization (HIAC, HALO, MFI)

Preferred

• Industry experience in formulation development or analytical testing

• Experience with formulation development.

• Familiarity with a programming language (Python, R, Matlab, or Visual Basic).

• Experience with liquid handling systems (TECAN, Hamilton, Beckman)

• Experience with biologics or viral vectors (such as AAV, monoclonal antibodies, vaccines) in the biopharma industry.

Key Skills/Abilities

• Strong organizational skills and detailed documentation abilities

• Able to quickly learn new skills and troubleshoot new problems

• Work well with multiple stakeholders

• Perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.

Internal/External Contacts

• Work with formulation scientists to design, execute, and analyze key experiments

• Work with automation scientists to improve automated methods

• Work with statisticians to analyze multivariate datasets

Other requirements

• Must be able to lift 25 pounds

• Must be flexible with work schedule and available to work extended hours as determined by management

• Must be able to wear appropriate clean room attire and all Personal Protective Equipment

• Must be able to stand for long periods

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.


Nearest Major Market: Philadelphia



Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

Company

At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
Website
Telephone
215-989-1149
Location
3737 Market Street
Suite 1300
Philadelphia
PA
19104
United States
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