Senior Scientist Ocular Immunology

Spark Therapeutics
Philadelphia, Pennsylvania. Hybrid and remote options available for select opportunities.
Salary not provided
Closing date
Aug 24, 2022

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Job Details

Immunology Group within Translational Research Department uses traditional and cutting-edge technology to ensure the safety of all therapeutic strategies at Spark. It is also responsible for the proof-of-concept studies design and execution for treatment of autoimmune diseases, choice of autoimmune indications and establishing the candidate development strategy from Research to Preclinical stage. The successful candidate’s primary responsibility will be to, in collaboration with other team members, propose, design, plan and coordinate execution of in vivo and in vitro studies with the goal of advancing autoimmune disease programs.

The (Senior) Scientist is going to be a member of Immunology Group within the Translational Research Department. He/She will be responsible for:

  • Participating in and/or overseeing autoimmune disease and immunology related projects in support of current and future company programs
  • Design, execute, troubleshoot, analyze, and interpret results from immune, bioanalytical, and molecular techniques involving genomics, transcriptomics (e.g., single-cell RNA sequencing, RNA in situ hybridization, etc.) and proteomics (exploration of post-translational modifications) in support of preclinical proof-of-concept Immunology Group studies
  • Therapeutic constructs design: transgene and protein engineering for gene and/or protein/cell therapy applications
  • Strategic planning, execution, and reporting of pre-clinical immunology studies; proposing novel strategies for treatment of autoimmune disorders
  • Keep abreast of new scientific and technical advances reported in the literature to support expansion and advancement of potential therapeutics for autoimmune diseases
Job Function and Description

  • Design, plan, execute and/or coordinate the execution of the proof-of-concept studies, including exploration of new technologies such as in vitro assay systems development for testing potential therapeutics and their in-depth molecular analysis
  • Strategic data analysis, review and reporting in the form of study reports and summary presentations
  • Optimization of proposed therapeutic constructs by means of transgene and protein engineering
  • Performance of cross-functional projects to support Immunology Group at large


  • Ph.D. in Immunology or related field
  • 3+ years of post-graduate experience in autoimmune disorders and/or gene therapy (AAV-based gene therapy is preferred)
  • Transgene and protein engineering know-how for gene and/or protein/cell therapy applications
  • Experience in assisting and mentoring research associates
  • Experience with design and execution of in vitro/in vivo experiments, data analysis, presentation, and scientific writing of data generated


Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.


At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
3737 Market Street
Suite 1300
United States

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