Histologist, Bioimaging

Spark Therapeutics
Philadelphia, Pennsylvania. Hybrid and remote options available for select opportunities.
Salary not provided
Closing date
May 26, 2022

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Life Sciences, Biotechnology
Organization Type

Job Details

Primary Duties:

The Incumbent will be an integral member of Spark’s histopathology team and support multiple gene therapy programs, from ocular and liver diseases to neurodegenerative disorders.

The primary role will be to collaborate with members of the research teams to acquire, curate and analyze experimental data, primarily consisting of digital histopathology images. An ideal candidate would be excited to play a role in shaping our fast-growing environment and in the development of our imaging infrastructure. Candidates with experience in newer histopathological techniques, such as lightsheet microscopy and spatial transcriptomics, are encouraged to apply.


  • Image acquisition and communication of data to support various projects
  • Test protocols and in-house tools to support analyses of datasets
  • Support automation and lab workflow systems for instrumentation and hardware
  • Generate technical reports and presentations
  • Trainings, lab meetings and administrative work

Education and Experience Requirements:

  • B.A./B.S. in a relevant field with 3-5 years of experience. Master’s degree preferred.
  • Must have 1-3 years of experience in biological image analysis, particularly in automation of image acquisition and batch processing of microscopy data
  • Familiarity with commercial imaging applications (i.e., HALO from Indica Labs) as well as freely available software (i.e. FIJI/Image J).
  • Preferred experience in spatial transcriptomics and/or lightsheet microscopy
  • Proven interpersonal and communication skills, including preparing written reports and oral presentations, as well as transparent work practices

Key Skills, Abilities, and Competencies:

  • Strong technical skills used in histopathology labs
  • Skilled in common image analysis applications, algorithms and modules
  • Comfortable with conversing with data scientists on topics like machine learning
  • Excellent writing and verbal communication skills.
  • Motivated, organized and enjoys working across functions and teams
  • Ability to analyze and troubleshoot experiments.
  • Strong motivation to support and train colleagues on how to develop and perform basic image acquisition and analysis protocols in a reproducible, unbiased manner

Complexity and Problem Solving:

  • Demonstrate independent problem-solving skills of technical issues; develop solutions to a variety of simple to moderately complex problems and effectively collaborate for addressing difficult issues.
  • Comfortable with working in both a vertical (management) as well as horizontal (colleagues across functional areas) manner to accomplish tasks and receive guidance.
  • Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
  • Exercise judgment within defined procedures and practices to determine appropriate action.


Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.


At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
3737 Market Street
Suite 1300
United States

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